Association of Streptococcus mutans collagen binding genes with severe childhood caries
Objective An important factor in the assessment of caries risk is the presence of specific oral microflora, especially Streptococcus mutans. Some S. mutans strains possess proteins capable of binding collagen, such as the Cnm and Cbm proteins. The aim is to determine the presence of S. mutans strain...
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Published in | Clinical oral investigations Vol. 24; no. 10; pp. 3467 - 3475 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Berlin/Heidelberg
Springer Berlin Heidelberg
01.10.2020
|
Subjects | |
Online Access | Get full text |
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Summary: | Objective
An important factor in the assessment of caries risk is the presence of specific oral microflora, especially
Streptococcus mutans.
Some
S. mutans
strains possess proteins capable of binding collagen, such as the Cnm and Cbm proteins. The aim is to determine the presence of
S. mutans
strains carrying collagen binding proteins in a group of subjects with severe early childhood caries (S-ECC).
Materials and methods
S. mutans
strains isolated from 15 S-ECC children were analyzed for
collagen binding domains
(
cbd
) of the
cnm
(
cbd/cnm
) and
cbm
(
cbd/cbm
) genes and their ability to bind to collagen.
Results
S. mutans
strains positive for
cbd/cnm
or
cbd/cbm
were only found in 3 subjects with the most severe caries profile, with one subject having both
cbd/cnm
and
cbd/cbm
, and the other two with one of each.
cnm/cbm
-positive
S. mutans
strains bound to collagen substrate more avidly compared with negative
S. mutans
strains from each of the three groups.
Conclusions
Our findings of an association between the presence of the collagen binding domains of the
cnm/cbm
genes in plaque
S. mutans
and the most aggressive form of caries profile in children offer a potential strategy to identify an individual’s risk for caries progression. Our study should be replicated in other settings and communities in longitudinal and longer-term studies.
Clinical relevance
Our data offer a potential tool in the caries risk management and assessment in children. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1432-6981 1436-3771 |
DOI: | 10.1007/s00784-020-03217-4 |