Efficient microwave-assisted synthesis of multivalent dendrimeric peptides using cycloaddition reaction (click) chemistry

Multivalent dendrimeric peptides were synthesized via a microwave-assisted Huisgen 1,3-dipolar cycloaddition between azido peptides and dendrimeric alkynes in yields ranging from 46 to 96%.

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Bibliographic Details
Published inChemical communications (Cambridge, England) no. 36; pp. 4581 - 4583
Main Authors Rijkers, DTS, van Esse, GW, Merkx, R, Brouwer, AJ, Jacobs, HJF, Pieters, RJ, Liskamp, RMJ
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 28.09.2005
Subjects
Azides - chemistry
Chemistry
Chemistry, Multidisciplinary
Cyclization
Dendrimers - chemical synthesis
Electrophoresis, Polyacrylamide Gel
Magnetic Resonance Spectroscopy
Microwaves
Peptides - chemical synthesis
Physical Sciences
Science & Technology
Solvents
Spectrometry, Mass, Electrospray Ionization
SOLID-PHASE
ADHESION
GLYCODENDRIMERS
INHIBITION
AZIDE
BINDING
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Summary:Multivalent dendrimeric peptides were synthesized via a microwave-assisted Huisgen 1,3-dipolar cycloaddition between azido peptides and dendrimeric alkynes in yields ranging from 46 to 96%.
ISSN:1359-7345
1364-548X
DOI:10.1039/b507975f