Serotonin and emotion regulation: the impact of tryptophan depletion on emotional experience, neural and autonomic activity

• Published in: Cognitive, affective, & behavioral neuroscience Vol. 23; no. 5; pp. 1414 - 1427
• Main Authors: Bîlc, Mirela I., Iacob, Alexandra, Szekely-Copîndean, Raluca D., Kiss, Béla, Ștefan, Maria-Georgia, Mureșan, Raul C., Pop, Claudia Felicia, Pițur, Simina, Szentágotai-Tătar, Aurora, Vulturar, Romana, MacLeod, Colin, Miu, Andrei C.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.10.2023
• Subjects: Behavioral Science and Psychology; Cognitive Psychology; Neurosciences; Psychology; Research Article; Frontal; Emotion; Serotonin; Emotion regulation; Autonomic
• ISSN: 1530-7026; 1531-135X
• DOI: 10.3758/s13415-023-01116-1

The involvement of serotonin in emotion and psychopathology has been extensively examined. Studies using acute tryptophan depletion (ATD) have found limited effects on mood and aggression, and one of the explanations suggests that serotonin may be involved in higher-order functions, such as emotion regulation. However, there is very limited evidence for this hypothesis. The present study investigated the impact of ATD on emotion regulation in a double-blind, placebo-controlled, crossover design. A sample of psychiatrically healthy men (N = 28) completed a cognitive task assessing reappraisal ability (i.e., the success of using reappraisal, an emotion regulation strategy, to modulate emotional responses), following ATD and placebo. EEG frontal activity and asymmetry, as well as heart-rate variability (HRV), also were assessed in the reappraisal task. Both frequentist and Bayesian methods were employed for statistical analysis. Results indicated that ATD reduced plasma tryptophan, and reappraisal was effective in modulating emotional experience in the emotion regulation task. However, ATD had no significant effect on reappraisal ability, frontal activity, and HRV. These results offer direct and compelling evidence that decreasing serotonin synthesis through ATD does not alter an emotion regulation ability that is considered crucial in mood and aggression and has been linked with transdiagnostic risk of psychopathology.