Aryl-aryl coupling via directed lithiation and oxidation

Aryl lithium reagents formed by directed lithiation reactions undergo transmetallation with copper( I) salts to form organocuprates, which may be efficiently oxidized to yield orthosubstituted biaryls.

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Bibliographic Details
Published inChemical communications (Cambridge, England) no. 20; pp. 2589 - 2590
Main Authors Surry, DS, Fox, DJ, Macdonald, SJF, Spring, DR
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 28.05.2005
Subjects
Chemistry
Chemistry, Multidisciplinary
Hydrocarbons, Aromatic - chemical synthesis
Lithium - chemistry
Molecular Structure
Oxidation-Reduction
Physical Sciences
Science & Technology
ULLMANN REACTION
DERIVATIVES
ELLAGITANNIN
STRATEGIES
BIARYLS
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Summary:Aryl lithium reagents formed by directed lithiation reactions undergo transmetallation with copper( I) salts to form organocuprates, which may be efficiently oxidized to yield orthosubstituted biaryls.
ISSN:1359-7345
1364-548X
DOI:10.1039/b501939g