Efficient synthesis of 2,4,5-trisubstituted 2,5-chiral tetrahydropyridines using a one-pot asymmetric azaelectrocyclization protocol

The stereocontrolled synthetic procedure for the preparation of 2,4,5-trisubstituted 2,5-chiral 1,2,5,6-tetrahydropyridines was established using a one-pot asymmetric azaelectrocyclization protocol; the generality of this protocol was demonstrated by synthesizing the title compounds with various ary...

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Published inChemical communications (Cambridge, England) no. 23; pp. 3363 - 3365
Main Authors Kobayashi, Toyoharu, Takeuchi, Kenichi, Miwa, Junichi, Tsuchikawa, Hiroshi, Katsumura, Shigeo
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 01.01.2009
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
MULTICOMPONENT REACTIONS
FORMAL SYNTHESIS
6-PI-AZAELECTROCYCLIZATION
INHIBITORY MECHANISM
AGE PIGMENT A2-E
CIS-1-AMINO-2-INDANOLS
PHOSPHOLIPASE A
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Summary:The stereocontrolled synthetic procedure for the preparation of 2,4,5-trisubstituted 2,5-chiral 1,2,5,6-tetrahydropyridines was established using a one-pot asymmetric azaelectrocyclization protocol; the generality of this protocol was demonstrated by synthesizing the title compounds with various aryl and alkenyl substituents at the C-2 position.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:1359-7345
1364-548X
DOI:10.1039/b900897g