Preoperatively diagnosed intraductal oncocytic papillary neoplasm of the pancreas with prominent invasion: a case report

• Published in: Clinical journal of gastroenterology Vol. 16; no. 5; pp. 772 - 778
• Main Authors: Nomaru, Ryohei, Ishida, Yusuke, Kitaguchi, Takanori, Koga, Takehiko, Tsuchiya, Naoaki, Nakashima, Ryo, Sato, Keisuke, Hamada, Yoshihiro, Hasegawa, Suguru, Hirai, Fumihito
• Format: Journal Article
• Language: English
• Published: Singapore Springer Nature Singapore 01.10.2023
• Subjects: Abdominal Surgery; Case Report; Colorectal Surgery; Gastroenterology; Hepatology; Medicine; Medicine & Public Health; Surgical Oncology; Intraductal papillary mucinous neoplasm; Pancreas; Endoscopic ultrasonography-guided fine-needle biopsy; Intraductal oncocytic papillary neoplasm
• ISSN: 1865-7257; 1865-7265
• DOI: 10.1007/s12328-023-01828-4

Previously considered as one of the less-invasive subtypes of intraductal papillary mucinous neoplasm, intraductal oncocytic papillary neoplasm (IOPN) has recently been acknowledged as a new entity of pancreatic tumor. We herein present a case of preoperatively diagnosable IOPN invasion in the stomach and colon. A 78-year-old woman was referred to our hospital for evaluation of anorexia and gastroesophageal reflux. Upper gastrointestinal endoscopy revealed a gastric subepithelial lesion with ulcerated mucosa that required hemostasis. Computed tomography revealed a 96-mm-diameter solid tumor with a well-defined border and centrally positioned necrotic area, extending from the stomach to the transverse colon and pancreatic tail. Because it was suspected to be a pancreatic solid tumor with direct stomach invasion, endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) was performed, which led to a preoperative diagnosis of IOPN. Moreover, laparoscopic pancreatosplenectomy, proximal gastrectomy, and transverse colectomy were performed. Analysis of the surgical specimen revealed that the tumor was IOPN and had invaded the stomach and transverse colon. Lymph node metastasis was also confirmed. These findings indicate that IOPN can manifest as an invasive tumor, and EUS-FNB may be equally helpful for assessing the invaded area of a cystic lesion as it is for a solid lesion.