Rome III and IV criteria are less discordant to diagnose irritable bowel syndrome in clinic patients than in community subjects

• Published in: Indian journal of gastroenterology Vol. 43; no. 6; pp. 1136 - 1143
• Main Authors: Ghoshal, Uday C., Mustafa, Uzma, Pandey, Vipin Kumar
• Format: Journal Article
• Language: English
• Published: New Delhi Springer India 01.12.2024
• Subjects: Abdominal Pain - etiology; Adult; Female; Gastroenterology; Hepatology; Humans; India - epidemiology; Irritable Bowel Syndrome - diagnosis; Male; Medicine; Medicine & Public Health; Middle Aged; Original Article; Severity of Illness Index; Surveys and Questionnaires; Young Adult; India; IBS-symptom severity score (IBS-SSS); Disorders of gut-brain interaction; Bristol stool form scale; Functional gastrointestinal disorders
• ISSN: 0254-8860; 0975-0711; 0975-0711
• DOI: 10.1007/s12664-024-01611-4

Background Though Rome IV criteria for irritable bowel syndrome (IBS) are less sensitive; they select Rome III patients with greater severity and consultation behavior. Since severity of IBS may determine consultation behavior, we compared Rome III and IV criteria in clinic patients and compared with earlier published data from Indian community hypothesizing that the diagnostic discordance between these criteria would be less in clinic than in community. Methods Tertiary clinic patients were screened for IBS using Hindi translated-validated Rome III and IV questionnaires; IBS symptom severity scores (IBS-SSS) was also assessed. Diagnostic discordance between Rome III and IV criteria for IBS was compared with earlier published Indian community data. Results Of 110 clinic patients with functional gastrointestinal disorders, 72 met IBS criteria (47 [42.7%], 22 [20%] and three [2.7%] both Rome III and IV criteria, Rome III criteria only and Rome IV criteria only, respectively). In contrast, of 40 IBS subjects from Indian community published earlier, nine (22.5%), 28 (70%) and three (7.5%) fulfilled both Rome III and IV, Rome III only, Rome IV only criteria, respectively. Clinic patients with IBS fulfilling both Rome III and IV criteria or Rome IV criteria had higher IBS-SSS than those fulfilling Rome III criteria only (295.3 ± 80.7 vs. 205.6 ± 65.7; p  < 0.00001). This difference was primarily related to pain severity and number of days with pain. Conclusion Discordance between Rome IV and Rome III criteria in tertiary care clinic patients is less than in community subjects with IBS in India. Graphical Abstract