Diastereoselective Ritter reactions of chiral secondary benzylic alcohols

An acid-catalysed Ritter reaction of chiral secondary benzylic alcohols enables diastereoselective access to chiral amides, which represent inter alia valuable intermediates for the synthesis of chiral 1,2-diamines and beta-amino acids.

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Bibliographic Details
Published inChemical communications (Cambridge, England) no. 16; pp. 2130 - 2132
Main Authors Rubenbauer, Philipp, Bach, Thorsten
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 01.01.2009
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
ALKENES
CRAFTS ALKYLATION REACTIONS
ACID
NITRILES
CONVERSION
DIPHENYL DISELENIDE
NITROACETAMIDATION
OLEFINS
ACETONITRILE
AMIDES
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Summary:An acid-catalysed Ritter reaction of chiral secondary benzylic alcohols enables diastereoselective access to chiral amides, which represent inter alia valuable intermediates for the synthesis of chiral 1,2-diamines and beta-amino acids.
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ISSN:1359-7345
1364-548X
DOI:10.1039/b901937e