The Relationship Between Plasma Oxytocin and Executive Functioning in Huntington’s Disease: A Pilot Study

The role of oxytocin (OT) in social cognition of patients with Huntington’s disease (HD) has been studied, but its impact on executive functioning has not been explored yet. Healthy controls, premanifest HD, and manifest HD participants underwent executive functioning assessment and OT plasma measur...

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Published inJournal of Huntington's disease Vol. 10; no. 3; pp. 349 - 354
Main Authors Fisher, Emily R., Rocha, Natalia P., Morales-Scheihing, Diego A., Venna, Venugopal Reddy, Furr-Stimming, Erin E., Teixeira, Antonio L., Rossetti, Maria A.
Format Journal Article
LanguageEnglish
Published London, England SAGE Publications 01.01.2021
IOS Press BV
Subjects
Cognition
Executive Function
Humans
Huntington Disease
Huntington's disease
Huntingtons disease
Neuropsychological Tests
Oxytocin
Pilot Projects
Social interactions
oxytocin
Huntington’s disease
depression
cognition
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Summary:The role of oxytocin (OT) in social cognition of patients with Huntington’s disease (HD) has been studied, but its impact on executive functioning has not been explored yet. Healthy controls, premanifest HD, and manifest HD participants underwent executive functioning assessment and OT plasma measurement. There were no significant group differences in plasma OT levels. Higher OT levels were associated with better executive functioning in premanifest HD participants. Our findings revealed an association between OT levels and depressive symptoms in premanifest and manifest HD participants. The potential role of OT in HD deserves further investigation.
ISSN:1879-6397
1879-6397
1879-6400
DOI:10.3233/JHD-210467