Neuromyelitis optica diagnosis in clinically isolated syndromes suggestive of multiple sclerosis

The authors assessed the extent of overlap between current diagnostic criteria of neuromyelitis optica (NMO) and multiple sclerosis (MS) by applying NMO criteria to a large cohort of 320 patients with clinically isolated syndromes (CIS). Twenty-three (7.2%) patients fulfilled NMO absolute criteria a...

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Bibliographic Details
Published inNeurology Vol. 66; no. 10; p. 1568
Main Authors Rubiera, M, Río, J, Tintoré, M, Nos, C, Rovira, A, Téllez, N, Montalban, X
Format Journal Article
LanguageEnglish
Published United States 23.05.2006
Subjects
Adult
Algorithms
Brain - pathology
Cohort Studies
Diagnosis, Differential
Female
Humans
Magnetic Resonance Imaging
Male
Multiple Sclerosis - diagnosis
Myelitis - etiology
Neuromyelitis Optica - complications
Neuromyelitis Optica - diagnosis
Optic Nerve - pathology
Optic Neuritis - etiology
Recurrence
Single-Blind Method
Spinal Cord - pathology
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Summary:The authors assessed the extent of overlap between current diagnostic criteria of neuromyelitis optica (NMO) and multiple sclerosis (MS) by applying NMO criteria to a large cohort of 320 patients with clinically isolated syndromes (CIS). Twenty-three (7.2%) patients fulfilled NMO absolute criteria at some time and 1 (0.3%) also fulfilled one major supportive criterion. Therefore, even by systematically applying NMO criteria in patients with CIS, NMO diagnosis is reached infrequently.
ISSN:1526-632X
DOI:10.1212/01.wnl.0000216233.56611.c2