A case of hemolytic uremic syndrome improved with nitric oxide

• Published in: Bone marrow transplantation (Basingstoke) Vol. 25; no. 1; pp. 109 - 110
• Main Authors: NAGITA, T. K. A, YOSHIMI, S, KOBAYASHI, K, KATAOKA, N
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing Group 2000
• Subjects: Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Bone Marrow Transplantation - adverse effects; Bone marrow, stem cells transplantation. Graft versus host reaction; Child; Diuretics, Osmotic - administration & dosage; Female; Hemolytic-Uremic Syndrome - drug therapy; Hemolytic-Uremic Syndrome - etiology; Hemolytic-Uremic Syndrome - metabolism; Humans; Isosorbide - administration & dosage; Medical sciences; Nitric Oxide - metabolism; Nitric Oxide Donors - administration & dosage; Pharmacology. Drug treatments; Stem cell transplantation; Transfusions. Complications. Transfusion reactions. Cell and gene therapy; Urinary system; Human; Kidney disease; Urinary system disease; Transdermal system; Hemolytic uremic syndrome; Isosorbide; Stem cell; Hematopoietic cell; Homograft; Hemopathy; Case study; Chemotherapy; Hemolytic anemia; Treatment; Nitric oxide; Renal failure; Bone marrow; Graft; Complication; Child
• ISSN: 0268-3369; 1476-5365
• DOI: 10.1038/sj.bmt.1702098

Hemolytic uremic syndrome (HUS) after transplantation is difficult to treat, and there is no consensus regarding optimal mode of treatment. We attached transdermal isosorbide tape as a nitric oxide (NO) donor to patients with HUS after bone marrow transplantation (BMT). This was very effective in ameliorating the hemolysis and increasing platelet numbers. We report here the successful use of an isosorbide in a patient with HUS after transplantation. Bone Marrow Transplantation (2000) 25, 109-110.