Angiopoietin-2 as a Prognostic Factor in Patients with Incurable Stage IV Colorectal Cancer

Purpose Angiopoietin (Ang), a ligand of the endothelium-specific receptor Tie-2 system, is associated with tumor growth and progression that depend on angiogenesis. The present study aimed to investigate the predictive potential of angiopoietin factors in incurable stage IV colorectal cancer (CRC) p...

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Published inJournal of gastrointestinal cancer Vol. 52; no. 1; pp. 237 - 242
Main Authors Munakata, Shinya, Ueyama, Takae, Ishihara, Haruna, Komiyama, Hiromitsu, Tsukamoto, Ryoichi, Kawai, Masaya, Takahashi, Makoto, Kojima, Yutaka, Tomiki, Yuichi, Sakamoto, Kazuhiro
Format Journal Article
LanguageEnglish
Published New York Springer US 01.03.2021
Subjects
Cancer Research
Gastroenterology
Internal Medicine
Medicine
Medicine & Public Health
Oncology
Original Research
Radiotherapy
Prognosis
Metastasis
Angiopoietin
Surgery
Colorectal cancer
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Summary:Purpose Angiopoietin (Ang), a ligand of the endothelium-specific receptor Tie-2 system, is associated with tumor growth and progression that depend on angiogenesis. The present study aimed to investigate the predictive potential of angiopoietin factors in incurable stage IV colorectal cancer (CRC) patients who have undergone primary tumor resection. Methods The study included 40 consecutive patients with incurable stage IV CRC who underwent primary tumor resection at our hospital between 2011 and 2015. Patients were divided into subgroups of low and high Ang-1, Ang-2, and Tie-2. Patient age and sex, tumor location, TNM stages, vascular invasion, chemotherapy, and overall survival were assessed. Results The cut-off values of Ang-1, Ang-2, and Tie-2 were 0.4, 1.8, and 15.0 ng/mL, respectively. Overall survival was significantly longer in the low Ang-2 group than in the high Ang-2 group. High Ang-2 levels were associated with age, N stage, and chemotherapy. Immunofluorescent staining of Ang-2 revealed that endothelial cells and cancer cells expressed Ang-2 in each case. Conclusions Our findings suggest that the serum Ang-2 level is associated with disease progression and is an important predictor of mortality in incurable stage IV CRC patients. Thus, it may be a useful prognostic biomarker in these patients.
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ISSN:1941-6628
1941-6636
DOI:10.1007/s12029-020-00392-1