Cutaneous intralymphatic histiocytosis associated with rheumatoid arthritis: report of a case and review of the literature

• Published in: The American journal of dermatopathology Vol. 29; no. 2; p. 165
• Main Authors: Catalina-Fernández, Inmaculada, Alvárez, Antonio Chaves, Martin, Félix Conde, Fernández-Mera, Jose Juan, Sáenz-Santamaría, Javier
• Format: Journal Article
• Language: English
• Published: United States 01.04.2007
• Subjects: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antigens, CD - analysis; Antigens, Differentiation, Myelomonocytic - analysis; Arthritis, Rheumatoid - complications; Arthritis, Rheumatoid - immunology; Arthritis, Rheumatoid - pathology; Cell Proliferation; Dermis - immunology; Dermis - pathology; Erythema - etiology; Erythema - immunology; Female; Histiocytes - immunology; Histiocytes - pathology; Histiocytosis - diagnosis; Histiocytosis - etiology; Histiocytosis - immunology; Histiocytosis - pathology; Humans; Immunohistochemistry - methods; Leg Dermatoses - diagnosis; Leg Dermatoses - etiology; Leg Dermatoses - immunology; Leg Dermatoses - pathology; Lymphatic Vessels - immunology; Lymphatic Vessels - pathology; Middle Aged
• ISSN: 0193-1091
• DOI: 10.1097/01.dad.0000251824.09384.46

Various dermatoses have been described associated with rheumatoid arthritis. Recently, a specific cutaneous lesion termed "intravascular histiocytosis" has been proposed as a new entity among these dermatoses. We report the case of a 50-year-old woman with rheumatoid arthritis for about 10 years who developed erythematous patches on the extensor surface of lower extremities. Histopathologically, the lesions showed intraluminal proliferation of CD68-positive histiocytes in vessels lined with endothelial cells expressing D2-40, a selective marker for lymphatic endothelium.