Relationship between lipoprotein(a) levels, cardiovascular outcomes and death in patients with chronic kidney disease: a systematic review of prospective studies

• Published in: Journal of nephrology Vol. 36; no. 6; pp. 1549 - 1559
• Main Authors: Barbagelata, Leandro, Masson, Walter, Corral, Pablo, Lavalle-Cobo, Augusto, Nogueira, Juan Patricio, Rosa Diez, Guillermo
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.07.2023
• Subjects: Medicine; Medicine & Public Health; Nephrology; Systematic Reviews; Urology; Systematic review; Lipoprotein(a); Chronic kidney disease; Dyslipidemia
• ISSN: 1724-6059; 1724-6059
• DOI: 10.1007/s40620-023-01590-3

Introduction and aim In the general population, high levels of lipoprotein(a) (Lp(a)) are an independent risk factor for atherosclerotic cardiovascular diseases. However, the information available in patients with chronic kidney disease (CKD) is less robust. The main objective of this updated systematic review of prospective studies was to analyze the association between elevated Lp(a) levels and cardiovascular outcomes or death in patients with CKD. Methods The PRISMA guidelines were used to carry out this systematic review. Randomized clinical trials or prospective observational studies that evaluated the association between Lp(a) levels and cardiovascular outcomes or death in CKD patients were searched in the current literature. Results Fifteen studies including 12,260 individuals were identified and considered eligible for this systematic review. In total, 14 prospective cohorts and one post-hoc analysis of a randomized clinical trial were analyzed. Eight studies evaluated hemodialysis patients, one study analyzed patients on peritoneal dialysis, while six studies evaluated subjects with different stages of CKD. Median follow-up duration ranged from 1 to 8.6 years. Our findings showed that elevated Lp(a) values were associated with a higher risk of cardiovascular events or death in most studies, despite adjusting for traditional risk factors. Conclusion The findings of this systematic review show that there is a positive association between Lp(a) levels and fatal and non-fatal cardiovascular events in patients with CKD. Graphical abstract