Awake brain mapping paradigms for nondominant hemisphere gliomas

• Published in: Neurosurgical focus Vol. 56; no. 2; p. E7
• Main Authors: Ekert, Justyna O, Sabsevitz, David S, Martin Del Campo, Isabel, Goyal, Anshit, Gillespie, Conor S, Middlebrooks, Erik H, Chaichana, Kaisorn L, Lee, Keng Siang, Sanchez-Garavito, Jesus E, Quiñones-Hinojosa, Alfredo
• Format: Journal Article
• Language: English
• Published: United States 01.02.2024
• Subjects: Brain Mapping; Brain Neoplasms - diagnostic imaging; Brain Neoplasms - pathology; Brain Neoplasms - surgery; Craniotomy; Frontal Lobe - surgery; Glioma - diagnostic imaging; Glioma - pathology; Glioma - surgery; Humans; Wakefulness; brain mapping; awake craniotomy; glioma; intraoperative testing; cognition; direct electrical stimulation
• ISSN: 1092-0684; 1092-0684
• DOI: 10.3171/2023.11.FOCUS23610

Traditionally, resection of nondominant hemisphere brain tumors was performed under general anesthesia. An improved understanding of right-lateralized neural networks has led to a paradigm shift in recent decades, where the right or nondominant hemisphere is no longer perceived as "functionally silent." There is an increasing interest in awake brain mapping for nondominant hemisphere resections. The objective of this study was to perform a comprehensive review of the existing brain mapping paradigms for patients with nondominant hemisphere gliomas undergoing awake craniotomies. In accordance with PRISMA guidelines, systematic searches of the Medline, Embase, and American Psychological Association PsycInfo databases were undertaken from database inception to July 1, 2023. Studies providing a description of the intraoperative mapping paradigm used to assess cognition during an awake craniotomy for resection of a nondominant hemisphere glioma were included. The search yielded 1084 potentially eligible articles. Thirty-nine unique studies reporting on 788 patients were included in the systematic review. The most frequently tested cognitive domains in patients with nondominant hemisphere tumors were spatial attention/neglect (17/39 studies, 43.6%), speech-motor/language (17/39 studies, 43.6%), and social cognition (9/39 studies, 23.1%). Within the frontal lobe, the highest number of positive mapping sites was identified for speech-motor/language, spatial attention/neglect, dual tasking assessing motor and language function, working memory, and social cognition. Within the parietal lobe, eloquence was most frequently found upon testing spatial attention/neglect, speech-motor/language, and calculation. Within the temporal lobe, the assessment of spatial attention/neglect yielded the highest number of positive mapping sites. Cognitive testing in the nondominant hemisphere is predominantly focused on evaluating two domains: spatial attention/neglect and the motor aspects of speech/language. Multidisciplinary teams involved in awake brain mapping should consider testing an extended range of functions to minimize the risk of postoperative deficits and provide valuable information about anatomo-functional organization of cognitive networks.