The suppressive effect of salmon muscle extracts containing anserine on lipid accumulation in rats fed with high fat diet

The anti-obesity effect of salmon muscle extracts containing anserine (SEAns) was investigated in Sprague-Dawley (SD) rats. The SEAns was orally administered to six-week-old male SD rats, and the rats were free to feed on a high fat diet for two weeks. Administration of the SEAns suppressed the incr...

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Published inNippon Suisan Gakkaishi Vol. 74; no. 6
Main Authors Takahashi, Y.(NICHIRO CORPORATION, Kawasaki, Kanagawa (Japan)), Kawarasaki, M, Hoshino, Y, Honmura, A, Enari, H
Format Journal Article
LanguageJapanese
Published 01.11.2008
Subjects
ADIPOSE TISSUE
CONTENIDO DE LIPIDOS
EXTRACTOS DE PESCADO
EXTRAIT DE POISSON
FISH EXTRACTS
IMIDAZOLE
IMIDAZOLES
LIPID CONTENT
LIPID METABOLISM
METABOLISME DES LIPIDES
METABOLISMO DE LIPIDOS
RAT
RATA
RATS
SALMON
SAUMON
TEJIDO ADIPOSO
TENEUR EN LIPIDES
TISSU ADIPEUX
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Summary:The anti-obesity effect of salmon muscle extracts containing anserine (SEAns) was investigated in Sprague-Dawley (SD) rats. The SEAns was orally administered to six-week-old male SD rats, and the rats were free to feed on a high fat diet for two weeks. Administration of the SEAns suppressed the increase of body weight and reduced lipid droplet of hepatic tissue, serum lipid level and the adipose tissue mass around testis and kidney. These findings suggested that not only anserine but also the other components in the SEAns were likely to have an effect. The SEAns also suppressed the accumulation of lipid in adipocytes with dose dependency. Furthermore, the SEAns was not observed to cause genetic toxicity by Rec-assay or oral acute toxicity on rats. Thus, the SEAns suppresses lipid accumulation and could be a safe functional food material which has an anti-obesity activity.
Bibliography:S20
L51
2009000450
Q03
ISSN:0021-5392
DOI:10.2331/suisan.74.1075