Spiral Arteries in Second Trimester of Pregnancy: When Is It Possible to Define Expected Physiological Remodeling as Abnormal?

• Published in: Reproductive sciences (Thousand Oaks, Calif.) Vol. 28; no. 4; pp. 1185 - 1193
• Main Authors: Olaya-C, Mercedes, Garrido, Marta, Franco, Jorge Andrés, Rodríguez, Jorge Luis, Vargas, Magda Jimena, Aula-Olivar, Ana, Quintero, Laura, Ramón y Cajal, Santiago
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.04.2021
• Subjects: Embryology; Maternal Fetal Medicine/Biology: Original Article; Medicine; Medicine & Public Health; Obstetrics/Perinatology/Midwifery; Reproductive Medicine; Vascular remodeling; Trophoblast invasion; Spiral arteries; Endovascular trophoblast; Preeclampsia
• ISSN: 1933-7191; 1933-7205
• DOI: 10.1007/s43032-020-00403-3

After undergoing remodeling, uterine spiral arteries turn into wide, flexible tubes, with low resistance. If remodeling does not occur, spontaneous abortions, intrauterine growth restriction, and pregnancy-related hypertensive disorders can ensue. Arterial transformation begins at a very early gestational stage; however, second quarter pregnancy histopathological samples have yet to pinpoint the exact moment when abnormal remodeling transpires. We examined 100 samples, taken from consecutive abortions at 12–23 gestational weeks. Following Pijnenborg and Smith guidelines, blinded pathologists analyzed clinical data on remodeling stages. Lab results showed that arterial remodeling is not synchronic in all vessels; a single sample can include various remodeling stages; neither is remodeling homogenous in a single vessel: change may be occurring in one part of the vessel, but not in another. To our knowledge, no one has published this finding. In the examined age group, Smith stage IV predominates; around week 14, substantial muscle and endothelium loss takes place. After week 17, endovascular or fibrin trophoblast does not usually occur. Although scant consensus exists on what defines preeclampsia etiology, it is clear that it involves abnormal remodeling in decidua vessels. Improved understanding requires further knowledge on both the physiological and pathological aspects of the remodeling process. We observed that muscle and endothelial tissues disappear from weeks 14–17, after which time reendothelization predominates. We list the expected proportion of spiral artery changes for each gestational age which, to date, has not been available.