The biocompatibility of polyaniline and polypyrrole 2: Doping with organic phosphonates

• Published in: Materials Science and Engineering: C Vol. 113; p. 110986
• Main Authors: Capáková, Zdenka, Radaszkiewicz, Katarzyna Anna, Acharya, Udit, Truong, Thanh Huong, Pacherník, Jiří, Bober, Patrycja, Kašpárková, Věra, Stejskal, Jaroslav, Pfleger, Jiří, Lehocký, Marián, Humpolíček, Petr
• Format: Journal Article
• Language: English
• Published: Netherlands 01.08.2020
• Subjects: Aniline Compounds - chemistry; Aniline Compounds - pharmacology; Animals; Biocompatible Materials - chemistry; Biocompatible Materials - pharmacology; Cell Differentiation - drug effects; Cell Line; Cell Survival - drug effects; Electric Conductivity; Hydrogen-Ion Concentration; Mice; Mouse Embryonic Stem Cells; Organophosphonates - chemistry; Polymers - chemistry; Polymers - pharmacology; Pyrroles - chemistry; Pyrroles - pharmacology; Conducting polymers biocompatibility; Embryonic stem cells; Polyaniline; Polypyrrole; Phosphonates
• ISSN: 0928-4931; 1873-0191
• DOI: 10.1016/j.msec.2020.110986

Conducting polymers (CP) can be used as pH- and/or electro-responsive components in various bioapplications, for example, in 4D smart scaffolds. The ability of CP to maintain conductivity under physiological conditions is, therefore, their crucial property. Unfortunately, the conductivity of the CP rapidly decreases in physiological environment, as their conducting salts convert to non-conducting bases. One of the promising solutions how to cope with this shortcoming is the use of alternative "doping" process that is not based on the protonation of CP with acids but on interactions relying in acidic hydrogen bonding. Therefore, the phosphonates (dimethyl phosphonate, diethyl phosphonate, dibutyl phosphonate, or diphenyl phosphonate) were used to re-dope two most common representatives of CP, polyaniline (PANI) and polypyrrole (PPy) bases. As a result, PANI doped with organic phosphonates proved to have significantly better stability of conductivity under different pH. It has also been shown that cytotoxicity of studied materials determined on embryonic stem cells and their embryotoxicity, determined as the impact on cardiomyogenesis and erythropoiesis, depend both on the polymer and phosphonate types used. With the exception of PANI doped with dibutyl phosphonate, all PPy-based phosphonates showed better biocompatibility than the phosphonates based on PANI.