Retention of gold nanoparticles in the structure of quasinematic layers formed by DNA molecules

Gold nanoparticles are shown to get incorporated into double-stranded DNA molecules forming quasinematic layers in the cholesteric liquid-crystalline dispersion particles. The process of nanoparticle incorporation results in distortion in an ordered arrangement of the neighboring dsDNA molecules in...

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Published inBiochemistry (Moscow). Supplement series A, Membrane and cell biology Vol. 5; no. 2; pp. 191 - 197
Main Authors Skuridin, S. G., Dubinskaya, V. A., Shtykova, E. V., Volkov, V. V., Rudoy, V. M., Dement’eva, O. V., Kuzmin, V. A., Lisitsyna, E. S., Zakhidov, S. T., Zelenina, I. A., Yevdokimov, Yu. M.
Format Journal Article
LanguageEnglish
Published Dordrecht SP MAIK Nauka/Interperiodica 01.06.2011
Springer Nature B.V
Subjects
Biochemistry
Biomedical and Life Sciences
Cell Biology
Deoxyribonucleic acid
DNA
Gold
Life Sciences
Molecular biology
Nanoparticles
double-stranded DNA
gold nanoparticles
small-angle X-ray scattering (SAXS)
structure of lyotropic liquid crystals of (bio)polymers
liquid-crystalline DNA dispersions
circular dichroism
toxicity of nanoparticles
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Summary:Gold nanoparticles are shown to get incorporated into double-stranded DNA molecules forming quasinematic layers in the cholesteric liquid-crystalline dispersion particles. The process of nanoparticle incorporation results in distortion in an ordered arrangement of the neighboring dsDNA molecules in a layer and in global spatial structure of particles of the dispersion, which may be one of the possible causes of the genotoxicity of gold nanoparticles.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:1990-7478
1990-7494
DOI:10.1134/S1990747811030068