A cellular scale numerical study of the effect of mechanical properties of erythrocytes on the near-wall motion of platelets

The effect of mechanical properties of erythrocytes on the near-wall motion of platelets was numerically studied with the immersed boundary method. Cells were modeled as viscous-fluid-filled capsules surrounded by hyper-elastic membranes with negligible thickness. The numerical results show that wit...

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Bibliographic Details
Published inActa mechanica Sinica Vol. 30; no. 2; pp. 274 - 280
Main Authors Xu, Jing, Wang, Xiao-Long, Liu, Yun-Qiao, Gong, Xiao-Bo
Format Journal Article
LanguageEnglish
Published Heidelberg The Chinese Society of Theoretical and Applied Mechanics; Institute of Mechanics, Chinese Academy of Sciences 01.04.2014
Subjects
Boundaries
Classical and Continuum Physics
Computational Intelligence
Engineering
Engineering Fluid Dynamics
Erythrocytes
Fluctuation
Mathematical models
Mechanical properties
Platelets
Pushing
Research Paper
Theoretical and Applied Mechanics
Walls
力学性能
数值模拟
数值研究
红细胞压积
蜂窝
血小板
运动
近壁
Near-wall motion of platelet
Hemodynamics
Immersed boundary method
Fluid-membrane interaction
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Summary:The effect of mechanical properties of erythrocytes on the near-wall motion of platelets was numerically studied with the immersed boundary method. Cells were modeled as viscous-fluid-filled capsules surrounded by hyper-elastic membranes with negligible thickness. The numerical results show that with the increase of hematocrit, the near-wall approaching of platelets is enhanced, with which platelets exhibit larger deformation and orientation angle of its near-wall tank-treading motion, and the lateral force pushing platelets to the wall is increased with larger fluctuation amplitude. Meanwhile the near-wall approaching is reduced by increasing the stiffness of erythrocytes.
Bibliography:Hemodynamics Fluid-membrane interaction Immersed boundary method Near-wall motion of platelet
The effect of mechanical properties of erythrocytes on the near-wall motion of platelets was numerically studied with the immersed boundary method. Cells were modeled as viscous-fluid-filled capsules surrounded by hyper-elastic membranes with negligible thickness. The numerical results show that with the increase of hematocrit, the near-wall approaching of platelets is enhanced, with which platelets exhibit larger deformation and orientation angle of its near-wall tank-treading motion, and the lateral force pushing platelets to the wall is increased with larger fluctuation amplitude. Meanwhile the near-wall approaching is reduced by increasing the stiffness of erythrocytes.
11-2063/O3
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0567-7718
1614-3116
DOI:10.1007/s10409-014-0006-0