IL-1RN and IL-1B gene polymorphisms and cerebral hemorrhagic events after traumatic brain injury

• Published in: Neurology Vol. 65; no. 7; p. 1077
• Main Authors: Hadjigeorgiou, G M, Paterakis, K, Dardiotis, E, Dardioti, M, Aggelakis, K, Tasiou, A, Xiromerisiou, G, Komnos, A, Zintzaras, E, Scarmeas, N, Papadimitriou, A, Karantanas, A
• Format: Journal Article
• Language: English
• Published: United States 11.10.2005
• Subjects: Adult; Age Factors; Brain Edema - etiology; Brain Edema - physiopathology; Brain Hemorrhage, Traumatic - genetics; Brain Hemorrhage, Traumatic - immunology; Brain Hemorrhage, Traumatic - physiopathology; DNA Mutational Analysis; Female; Gene Frequency; Genetic Predisposition to Disease - genetics; Genetic Testing; Genotype; Glasgow Coma Scale; Humans; Interleukin 1 Receptor Antagonist Protein; Interleukin-1 - genetics; Male; Middle Aged; Minisatellite Repeats - genetics; Models, Neurological; Neurosurgical Procedures; Odds Ratio; Polymorphism, Genetic - genetics; Prospective Studies; Sex Factors; Sialoglycoproteins - genetics
• ISSN: 1526-632X
• DOI: 10.1212/01.wnl.0000178890.93795.0e

To investigate the association of (variable number tandem repeat) interleukin (IL) 1RN and (-511) IL-1B gene polymorphisms with brain hemorrhagic events after traumatic brain injury (TBI). Data from brain CT, Glasgow Coma Scale (GCS) at admission, and 6-month Glasgow Outcome Scale (GOS) and modified Rankin Scale (mRS) were collected for 151 prospectively recruited patients with TBI. IL-1RN and IL-1B genotypes were determined using standard methods. Presence vs absence of any type of brain hemorrhage was the main outcome. Type of brain hemorrhage, GCS at admission, and 6-month GOS and mRS were secondary outcomes. Odd ratios (ORs) and corresponding 95% CI were calculated using logistic regression analyses. In adjusted models, the associations were controlled for age, gender, diffuse brain edema, volume of intracranial hematoma, neurosurgical intervention, and GCS at admission. p values less than 0.01 were considered significant. Compared with noncarriers, IL-1RN allele 2 carriers had higher odds of having cerebral hemorrhages after TBI (adjusted OR = 4.57; 95% CI = 1.67 to 12.96; p = 0.004). The associations for (-511) IL-1B polymorphism were not significant. There is an association between the presence of interleukin-1RN allele 2 and posttraumatic brain hemorrhage.