Potentials of human bile acids and their salts in pharmaceutical nano delivery and formulations adjuvants

• Published in: Technology and health care Vol. 28; no. 3; pp. 325 - 335
• Main Authors: Kecman, S., Škrbić, R., Badnjevic Cengic, Alma, Mooranian, A., Al-Salami, H., Mikov, M., Golocorbin-Kon, S.
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.01.2020; Sage Publications Ltd
• Subjects: Acids; Adjuvants; Bile; Bile acids; Bile Acids and Salts - chemistry; Bioavailability; Biological Availability; Drug Administration Routes; Drug carriers; Drug Carriers - chemistry; Drug delivery; Drugs; Formulations; Humans; Liposomes; Liposomes - chemistry; Literature reviews; Micelles; Modulators; Molecular structure; Nanoparticles - chemistry; Nanotechnology; Salts; nano-structures; Bile acids; drug delivery; bilosomes; absorption enhancers
• ISSN: 0928-7329; 1878-7401; 1878-7401
• DOI: 10.3233/THC-191845

In the last decade, the attention of the scientific community has been focused on bile acids and their salts as systems for the transportation of drugs; specifically their role as carriers and integration into nanomedicine. Bile acids can play a critical role as drug carriers in the form of chemical conjugates, complexation, mixed micelles formation as well as stabilized bile acid liposomes (bilosomes). The unique molecular structure and interaction of these amphiphilic-steroidal compounds make them an interesting subject of research. This review is based on literature research in order to emphasize the importance of bile acids and their salts as absorption modulators in order to improve therapeutic potentials of low bioavailability drugs.