Immunoreactive Cu-SOD and Mn-SOD in lymphocytes sub-populations from normal and trisomy 21 subjects according to age

Copper and manganese superoxide dismutases (Cu-SOD and Mn-SOD) were measured by radioimmunoassay in B and T lymphocytes and macrophages, in patients with trisomy 21 and in matched controls. In the controls, Cu-SOD was present in greater amounts than Mn-SOD and there were quantitative differences in...

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Published inLife sciences (1973) Vol. 32; no. 8; p. 895
Main Authors Baeteman, M A, Baret, A, Courtière, A, Rebuffel, P, Mattei, J F
Format Journal Article
LanguageEnglish
Published Netherlands 21.02.1983
Subjects
Adolescent
Adult
Age Factors
B-Lymphocytes - enzymology
Cell Separation
Child
Child, Preschool
Copper
Down Syndrome - enzymology
Down Syndrome - immunology
Female
Humans
Macrophages - enzymology
Male
Manganese
Superoxide Dismutase - blood
T-Lymphocytes - enzymology
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Summary:Copper and manganese superoxide dismutases (Cu-SOD and Mn-SOD) were measured by radioimmunoassay in B and T lymphocytes and macrophages, in patients with trisomy 21 and in matched controls. In the controls, Cu-SOD was present in greater amounts than Mn-SOD and there were quantitative differences in the distribution in the three cellular sub-populations. In trisomy 21, levels of Cu-SOD were raised, with no change in levels of Mn-SOD, supporting the theory of a gene dosage effect. There were significant positive and negative correlations between age and Cu-SOD levels in controls, and a correlation approaching significance for Mn-SOD. In trisomy 21, there was no correlation between age and Cu-SOD levels, and the only significant correlation for Mn-SOD was for B lymphocytes.
ISSN:0024-3205
DOI:10.1016/0024-3205(83)90227-8