Bacteriophage Therapy of Ventilator-associated Pneumonia and Empyema Caused by Pseudomonas aeruginosa

The case study of a 77-year-old woman who underwent a right posterolateral mini-thoracotomy for resection of a right lower lobe adenocarcinoma with mediastinal node sampling is discussed. Her past medical history was significant for a 60 pack-year smoking history and hypersensitivity reactions to mu...

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Bibliographic Details
Published inAmerican journal of respiratory and critical care medicine Vol. 200; no. 9; pp. 1179 - 1181
Main Authors Maddocks, Susan, Fabijan, Aleksandra Petrovic, Ho, Josephine, Lin, Ruby C Y, Ben Zakour, Nouri L, Dugan, Chris, Kliman, Ivana, Branston, Steven, Morales, Sandra, Iredell, Jonathan R
Format Journal Article
LanguageEnglish
Published United States American Thoracic Society 01.11.2019
Subjects
Aged
Antibiotics
Empyema - microbiology
Empyema - therapy
Female
Humans
Intubation
Lung cancer
Phage Therapy
Pneumonia, Ventilator-Associated - microbiology
Pneumonia, Ventilator-Associated - therapy
Pseudomonas aeruginosa
Pseudomonas Infections - therapy
Smoking
Surgical outcomes
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Summary:The case study of a 77-year-old woman who underwent a right posterolateral mini-thoracotomy for resection of a right lower lobe adenocarcinoma with mediastinal node sampling is discussed. Her past medical history was significant for a 60 pack-year smoking history and hypersensitivity reactions to multiple antibiotics (penicillins, cephalosporins, trimethoprim-sulfamethoxazole, and macrolides). Tumor excision was macroscopically complete, and an intercostal catheter (ICC) with underwater seal was left in situ. Sputum cultures taken on the day of intubation reported a moderate pure growth of P. aeruginosa susceptible to piperacillin-tazobactam, ciprofloxacin, and meropenem.
ISSN:1073-449X
1535-4970
DOI:10.1164/rccm.201904-0839LE