Impact of presence of HBs antigen and anti-hepatitis C virus and anti-cytomegalovirus antibodies on transplanted kidney survival

• Published in: Transplantation proceedings Vol. 38; no. 1; pp. 136 - 138
• Main Authors: SIENKO, J, WISNIEWSKA, M, MIZERSKI, A, TEJCHMAN, K, NOWACKI, M, OSTROWSKI, M, BOHATYREWICZ, R, CIECHANOWSKI, K, ROZANSKI, J, DOMANSKI, L, MYSLAK, M, KAMINSKI, M, SULIKOWSKI, T, PABISIAK, K, ROMANOWSKI, M
• Format: Conference Proceeding Journal Article
• Language: English
• Published: New York, NY Elsevier Science 2006
• Subjects: Adult; Antibodies, Viral - blood; Biological and medical sciences; Cytomegalovirus - isolation & purification; Cytomegalovirus Infections - epidemiology; Female; Follow-Up Studies; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Graft Survival - physiology; Hepatitis B - epidemiology; Hepatitis B Antigens - blood; Hepatitis C - epidemiology; Hepatitis C Antibodies - blood; Human viral diseases; Humans; Infectious diseases; Kidney Transplantation - mortality; Kidney Transplantation - physiology; Male; Medical sciences; Postoperative Complications - virology; Risk Factors; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Time Factors; Tissue, organ and graft immunology; Viral diseases; Viral hepatitis; Graft(material); Prognosis; Hepatic disease; Transplantation; Homotransplantation; Betaherpesvirinae; Kidney; Human cytomegalovirus; Surgery; Graft; Viral hepatitis C; Opportunistic infection; Hepatitis B surface antigen; Antibody; Herpesviridae; Survival; Infection; Virus; Medicine; Treatment; Urinary system; Viral disease; Digestive diseases; Flaviviridae; Hepatitis C virus; Hepacivirus
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/j.transproceed.2005.11.089

Infections are one of the most common complications after organ transplantation. Viral infections such as hepatitis type B (HBV) and C (HCV) or cytomegalovirus (CMV) infections are among the most serious ones. A high frequency of HBV and HCV infections has been recognized in kidney recipients. Viral infections play a special role in graft recipients because of clinical symptoms influencing graft function and recipient survival. Immunosuppressive treatment to decrease immunological reactions after organ transplantation may increase the risk of viral infections. The aim of this study was to evaluate the impact of the presence of HBs antigen and HCV and CMV antibodies on patient and graft survivals. Two hundred one enrolled kidney transplantation patients (96 women and 105 men) were treated with the same immunosuppressive regimen. Age, sex, and viral state (HBs antigen, anti-HCV and anti-CMV antibodies) were evaluated in every patient. Statistical analysis was performed with the Gompertz model, Kaplan-Meier curves and Cox proportional hazard tests. The presence of HBs antigen was detected in 161 patients (20.4%), HCV antibodies in 61 recipients (30.3%); and CMV antibodies in 12 patients (5.9%). Eighty-seven recipients (43.4%) were seronegative. Average recipient age was 38.5 years. Time of graft function was independent of the presence of HBs antigen or HCV or CMV antibodies.