Relationship between Aging and Renal Function: A Positron Emission Tomographic Study

Blood volume (V), blood flow (F) and glomerular filtration rate (GFR) per 100 g (100 ml) of kidney were calculated with C15O, H215O and 68Ga-EDTA, to study age-related changes per unit tissue in 19 subjects using positron emission tomography. Age was negatively correlated with V, F and GFR. The agin...

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Published inRADIOISOTOPES Vol. 39; no. 11; pp. 507 - 509
Main Authors YAMASHITA, Masato, MIZUKAWA, Norihiko, INABA, Tadashi, USHIJIMA, Yo, FURUYA, Seiichi, ODA, Yohei, NAKAGAWA, Shuichi, NAKAHASHI, Hisamitsu
Format Journal Article
LanguageJapanese
Published Japan Japan Radioisotope Association 1990
Subjects
Adult
age
Aged
Aging - physiology
blood flow
blood volume
Blood Volume - physiology
Female
gallium-68 ethylenediaminetetraacetic acid
glomerular filtration rate
Glomerular Filtration Rate - physiology
Humans
Kidney - diagnostic imaging
Kidney - physiology
Male
Middle Aged
oxygen-15 carbon monoxide
oxygen-15 water
Radioisotope Renography
Renal Circulation - physiology
Tomography, Emission-Computed
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ISSN0033-8303
1884-4111
DOI10.3769/radioisotopes.39.11_507

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Summary:Blood volume (V), blood flow (F) and glomerular filtration rate (GFR) per 100 g (100 ml) of kidney were calculated with C15O, H215O and 68Ga-EDTA, to study age-related changes per unit tissue in 19 subjects using positron emission tomography. Age was negatively correlated with V, F and GFR. The agingrelated decrease in V was less marked than those in F and GFR. Analysis by regression formula induced that F, GFR for subjects in their 70 s are 76%, 46% and 55% for those in their 20 s, respectively.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0033-8303
1884-4111
DOI:10.3769/radioisotopes.39.11_507