Effect of Intravascular Isotope Content on the Isotopic Determination of Coronary Collateral Blood Flow

Simultaneous determinations of myocardial blood volume (using I-PVP), myocardial blood flow (using H2O), and coronary collateral myocardial blood flow (using retrograde flow) were made in dogs after left circumflex artery ligation. Intravascular H2O content at the end of the H2O infusion was calcula...

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Published inCirculation research Vol. 16; no. 6; pp. 537 - 544
Main Authors Bloor, Colin M, Roberts, Lathrop E
Format Journal Article
LanguageEnglish
Published United States American Heart Association, Inc 01.06.1965
Subjects
Animals
Blood Circulation
Blood Volume
Collateral Circulation
Coronary Vessels
Dogs
Heart
Iodine Isotopes
Myocardium
Old Medline
Povidone
Regional Blood Flow
Tritium
MYOCARDIUM
IODINE ISOTOPES
POLYVINYLPYRROLIDONE
CORONARY VESSELS
BLOOD CIRCULATION
DOGS
EXPERIMENTAL LAB STUDY
REGIONAL BLOOD FLOW
COLLATERAL CIRCULATION
TRITIUM
BLOOD VOLUME
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Summary:Simultaneous determinations of myocardial blood volume (using I-PVP), myocardial blood flow (using H2O), and coronary collateral myocardial blood flow (using retrograde flow) were made in dogs after left circumflex artery ligation. Intravascular H2O content at the end of the H2O infusion was calculated as the product of myocardial blood volume and the final arterial H2O concentration.When correction is made for intravascular H2O content the resulting flow measured by H2O is nearly identical to the retrograde flow. These results indicate that radioactive isotopes can be used to measure blood flow if correction is made for the intravascular isotope content. The identity of corrected H2O flows with retrograde flows also indicates the applicability of isotopic methods for the measurement of coronary collateral blood flow.
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ISSN:0009-7330
1524-4571
DOI:10.1161/01.RES.16.6.537