Adenosine A3 receptor stimulation and cerebral ischemia

• Published in: European journal of pharmacology Vol. 263; no. 1-2; pp. 59 - 67
• Main Authors: VON LUBITZ, D. K. J. E, LIN, R. C.-S, POPIK, P, CARTER, M. F, JACOBSON, K. A
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier 22.09.1994
• Subjects: Adenosine - analogs & derivatives; Adenosine - pharmacology; Animals; Antianginal agents. Coronary vasodilator agents; Biological and medical sciences; Blood Pressure - drug effects; Brain Ischemia - drug therapy; Cardiovascular system; Cerebrovascular Circulation - drug effects; Drug Administration Schedule; Female; Gerbillinae; Medical sciences; Neurons - drug effects; Pharmacology. Drug treatments; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Xanthines - pharmacology; Regional blood flow; Nervous system diseases; Agonist; Mortality; Rodentia; Cardiovascular disease; Survival; Cerebral disorder; Vascular disease; Vertebrata; Chemotherapy; Mammalia; Treatment; Ischemia; Animal; Central nervous system disease; Antiïschemic; Hemodynamics; Gerbil; Cerebrovascular disease; Brain (vertebrata)
• ISSN: 0014-2999; 1879-0712
• DOI: 10.1016/0014-2999(94)90523-1

Chronic treatment with the selective adenosine A3 receptor agonist N6-(3-iodobenzyl)adenosine-5'-N-methylcarboxamide (IB-MECA) administered prior to either 10 or 20 min forebrain ischemia in gerbils resulted in improved postischemic cerebral blood circulation, survival, and neuronal preservation. Opposite effects, i.e., impaired postischemic blood flow, enhanced mortality, and extensive neuronal destruction in the hippocampus were seen when IB-MECA was given acutely. Neither adenosine A1 nor A2 receptors are involved in these actions. The data indicate that stimulation of adenosine A3 receptors may play an important role in the development of ischemic damage, and that adenosine A3 receptors may offer a new target for therapeutic interventions.