Fibroblast stimulation in schistosomiasis. IV. Isolated egg granulomas elaborate a fibroblast chemoattractant in vitro

Schistosoma mansoni, serum-free supernatants from cultures of hepatic egg granulomas isolated from infected mice contained activity that stimulated directional migration of human and guinea pig dermal fibroblasts in modified Boyden chambers, this fibroblast chemotactic activity was also detected in...

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Bibliographic Details
Published inThe Journal of immunology (1950) Vol. 130; no. 3; pp. 1371 - 1375
Main Authors Wyler, D.J, Postlethwaite, A.E
Format Journal Article
LanguageEnglish
Published United States Am Assoc Immnol 01.03.1983
Subjects
Animals
Chemotactic Factors - analysis
Chemotactic Factors - biosynthesis
Chromatography, Gel
Female
Fibroblasts - immunology
Fibronectins - immunology
granuloma
Granuloma - immunology
macrophages
Mice
Mice, Inbred C57BL
Pathology, Trematoda
Schistosoma mansoni
Schistosomiasis - immunology
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Summary:Schistosoma mansoni, serum-free supernatants from cultures of hepatic egg granulomas isolated from infected mice contained activity that stimulated directional migration of human and guinea pig dermal fibroblasts in modified Boyden chambers, this fibroblast chemotactic activity was also detected in culture supernatants of granuloma adherent cells highly enriched for macrophages
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ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.130.3.1371