Methylanthranilate, a Food Fragrance Attenuates Skin Pigmentation through Downregulation of Melanogenic Enzymes by cAMP Suppression

Methyl anthranilate (MA) is a botanical fragrance used in food flavoring with unexplored potential in anti-pigment cosmetics. MA dose-dependently reduced melanin content without affecting cell viability, inhibited dendrite elongation and melanosome transfer in the co-culture system of human melanoma...

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Published inBiomolecules & therapeutics Vol. 32; no. 2; pp. 231 - 239
Main Authors Park, Heui-Jin, Kim, Kyuri, Lee, Eun-Young, Hillman, Prima F, Nam, Sang-Jip, Lim, Kyung-Min
Format Journal Article
LanguageEnglish
Published Korea (South) The Korean Society of Applied Pharmacology 01.03.2024
한국응용약물학회
Subjects
Original
약학
Melanoderm
Skin pigmentation
Melanogenesis
Methyl anthranilate
Anti-ppigmentary agent
Cyclic adenosine monophosphate
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Summary:Methyl anthranilate (MA) is a botanical fragrance used in food flavoring with unexplored potential in anti-pigment cosmetics. MA dose-dependently reduced melanin content without affecting cell viability, inhibited dendrite elongation and melanosome transfer in the co-culture system of human melanoma cells (MNT-1) and human keratinocyte cell line (HaCaT), and downregulated melanogenic genes, including tyrosinase, tyrosinase-related protein 1 and 2 (TRP-1, TRP-2). Additionally, MA decreased cyclic adenosine monophosphate (cAMP) production and exhibited a significant anti-pigmentary effect in Melanoderm™. These results suggest that MA is a promising anti-pigmentary agent for replacing or complementing existing anti-pigmentary cosmetics.
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The first two authors contributed equally to this work.
ISSN:1976-9148
2005-4483
DOI:10.4062/biomolther.2023.103