Frequency-specific Alterations of Functional Hub in Generalized Tonic-clonic Seizure

• Published in: The International journal of networked and distributed computing (Online) Vol. 4; no. 4; pp. 221 - 230
• Main Authors: Zhang, Zhe, Cheng, Huiyan, Chen, Xuhui, Ma, Chaolin
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.10.2016; Springer
• Subjects: Research Article; Resting-state; GTCS; Hub; CEEMD; Frequency-specific; Resting-state; CEEMD; Frequency-specific; Hub; GTCS
• ISSN: 2211-7938; 2211-7946; 2211-7946
• DOI: 10.2991/ijndc.2016.4.4.3

Resting-state functional magnetic resonance imaging (rs-fMRI) has shown aberrant brain functional networks at a conventional low-frequency range (0.01–0.08 Hz) in individuals with generalized tonic-clonic seizure (GTCS). However, it is unclear how functional networks hubs change across different frequency bands in GTCS patients. In this study, we applied a data-driven method called complementary ensemble empirical mode decomposition (CEEMD) to decompose the whole brain blood oxygen level-dependent (BOLD) time series into five frequency-specific bands. Then, we compared alterations of frequency-specific functional hub across five different frequency bands in 21 GTCS patients to 22 normal control (NC) subjects. CTCS patients showed aberrant functional hubs predominately at some particular frequency bands and primary in the default mode network (DMN) and the somatomotor network (SMN). Furthermore, we found these hubs located in the DMN and the SMN at some specific bands (0.015–0.025 Hz, 0.12–0.25 Hz) were associated with disease severity. These findings highlight the role of frequency-specific functional hub, and may helpfully uncover abnormal neuronal activity in patients with GTCS at frequency-specific bands.