Microwave-Assisted Carbonyl-Carbonyl Coupling Route for the Preparation of a Useful Intermediate in the Synthesis of Carbapenems

Microwave-assisted organic synthesis has been used for the cyclization of a monocyclic oxoamide to the corresponding bicyclic derivative via a Wittig-type coupling by means of phosphite reagents. The parameters influencing the reaction yields under microwave (dielectric heating) and classical condit...

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Bibliographic Details
Published inSynthetic communications Vol. 39; no. 12; pp. 2151 - 2160
Main Authors Xia, Zhining, Long, Sha, Xiao, Shangyou, Zou, Xiaoping, D'Aurizio, Antonio, Panunzio, Mauro
Format Journal Article
LanguageEnglish
Published PHILADELPHIA Taylor & Francis Group 22.05.2009
Taylor & Francis
Subjects
Carbapenem
Chemistry
Chemistry, Organic
imipenem
MAOS (microwave-assisted organic synthesis)
phosphite-mediated cyclization
Physical Sciences
Science & Technology
Wittig intramolecular reaction
Carbapenem
phosphite-mediated cyclization
Wittig intramolecular reaction
CYCLIZATION REACTION
imipenem
PENEMS
MAOS (microwave-assisted organic synthesis)
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Summary:Microwave-assisted organic synthesis has been used for the cyclization of a monocyclic oxoamide to the corresponding bicyclic derivative via a Wittig-type coupling by means of phosphite reagents. The parameters influencing the reaction yields under microwave (dielectric heating) and classical conditions (convective heating) have been evaluated.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397910802638586