Experimental and theoretical studies of imidazole based chemosensor for Palladium and their biological applications

• Published in: Journal of photochemistry and photobiology. A, Chemistry. Vol. 385; p. 112092
• Main Authors: Suresh, Shanmugam, Bhuvanesh, Nanjan, Raman, Arunachalam, Sugumar, Paramasivam, Padmanabhan, Dhanasekaran, Easwaramoorthi, Shanmugam, Ponnuswamy, Mondikalipudur Nanjappagounder, Kavitha, Subbiah, Nandhakumar, Raju
• Format: Journal Article
• Language: English
• Published: Lausanne Elsevier B.V 01.12.2019; Elsevier BV
• Subjects: Antimicrobial; Aqueous solutions; Artemia; Bio imaging; Cations; Chemical sensors; Chemoreceptors; Chemosensor; Colorimetric; Density functional theory; DFT; Fluorescence; Imidazole; Metal ions; Molecular docking; Palladium; Pd2+ ion; Saline water; Selectivity; Stoichiometry; Antimicrobial; DFT; Chemosensor; Pd2+ ion; Fluorescence; Bio imaging; Molecular docking; Colorimetric
• ISSN: 1010-6030; 1873-2666
• DOI: 10.1016/j.jphotochem.2019.112092

[Display omitted] •Imidazole derivative bearing a thiphene group (L1) senses Pd2+ sensor via turn on-off mechanism.•The absorbance intensity of probe L1 enhances, the fluorescence intensity quenches with Pd2+ ions.•Density Functional Theory (DFT) calculations were used to study the electronic properties.•The intracellular Pd2+ ion detection in living cells was performed using probe L1 on brine shrimp nauplii (Artemia salina). An imidazole derivative (probe L1) bearing a thiophene group was developed as an ON-OFF fluorescent chemosensor for palladium ions. The UV–vis absorption and fluorescence spectral behavior of probe L1 towards various cations were investigated in HEPES buffer aqueous solution. The absorbance intensity of probe L1 considerably enhanced whereas the fluorescence emission intensity was quenched in the presence of Pd2+ ions, while the presence of other metal ions had no notable interference. The stoichiometry of the complex was determined using Job’s plot and a plausible recognition mechanism of probe L1 and Pd2+ is proposed. Density Functional Theory (DFT) calculations were used to study the electronic properties and to optimize the structure on the selectivity of Pd2+ ions and are correlated with the experimental results. The intracellular Pd2+ ion detection in living cells was performed using probe L1 on brine shrimp nauplii (Artemia salina) up to 20 μg/mL.