pH- and temperature-sensitive semi-interpenetrating network hydrogels composed of poly(acrylamide) and poly(γ-glutamic acid) as amoxicillin controlled-release system

• Published in: Polymer bulletin (Berlin, Germany) Vol. 68; no. 1; pp. 197 - 207
• Main Authors: Rodríguez-Félix, D. E., Pérez-Martínez, C. J., Castillo-Ortega, M. M., Pérez-Tello, M., Romero-García, J., Ledezma-Pérez, A. S., Del Castillo-Castro, T., Rodríguez-Félix, F.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 2012; Springer; Springer Nature B.V
• Subjects: Acids; Acrylamide; Aminoacid polymers; Amoxicillin; Antibiotics; Applied sciences; Aqueous solutions; Biological and medical sciences; Buffer solutions; Calibration; Characterization and Evaluation of Materials; Chemistry; Chemistry and Materials Science; Complex Fluids and Microfluidics; Equilibrium; Equilibrium conditions; Exact sciences and technology; Experiments; General pharmacology; Glutamic acid; Hydrogels; Interpenetrating networks; Kinetics; Mechanical properties; Medical sciences; Organic Chemistry; Original Paper; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Physical Chemistry; Physicochemistry of polymers; Polymer Sciences; Polymers; Soft and Granular Matter; Synthetic biopolymers; Semi-interpenetrating networks; Amoxicillin controlled release; Polymer gels; Poly(acrylamide); Poly(γ-glutamic acid); Control release polymer; Temperature effect; Drug carrier; pH effect; Semiinterpenetrating polymer network; Experimental study; Empirical model; Modeling; Aminoacid polymer; Antibiotic; Amoxicillin; Acrylamide polymer; Glutamic acid polymer; Kinetics; Hydrogel; Release

Hydrogels of semi-interpenetrating networks composed of poly(acrylamide) (PAAm) and poly(γ-glutamic acid) (γ-PGA) with different proportions were studied as potential amoxicillin controlled-release devices. The effects of the hydrogels composition, pH, and temperature on the kinetics and final relea...