pH- and temperature-sensitive semi-interpenetrating network hydrogels composed of poly(acrylamide) and poly(γ-glutamic acid) as amoxicillin controlled-release system

• Published in: Polymer bulletin (Berlin, Germany) Vol. 68; no. 1; pp. 197 - 207
• Main Authors: Rodríguez-Félix, D. E., Pérez-Martínez, C. J., Castillo-Ortega, M. M., Pérez-Tello, M., Romero-García, J., Ledezma-Pérez, A. S., Del Castillo-Castro, T., Rodríguez-Félix, F.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 2012; Springer; Springer Nature B.V
• Subjects: Acids; Acrylamide; Aminoacid polymers; Amoxicillin; Antibiotics; Applied sciences; Aqueous solutions; Biological and medical sciences; Buffer solutions; Calibration; Characterization and Evaluation of Materials; Chemistry; Chemistry and Materials Science; Complex Fluids and Microfluidics; Equilibrium; Equilibrium conditions; Exact sciences and technology; Experiments; General pharmacology; Glutamic acid; Hydrogels; Interpenetrating networks; Kinetics; Mechanical properties; Medical sciences; Organic Chemistry; Original Paper; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Physical Chemistry; Physicochemistry of polymers; Polymer Sciences; Polymers; Soft and Granular Matter; Synthetic biopolymers; Semi-interpenetrating networks; Amoxicillin controlled release; Polymer gels; Poly(acrylamide); Poly(γ-glutamic acid); Control release polymer; Temperature effect; Drug carrier; pH effect; Semiinterpenetrating polymer network; Experimental study; Empirical model; Modeling; Aminoacid polymer; Antibiotic; Amoxicillin; Acrylamide polymer; Glutamic acid polymer; Kinetics; Hydrogel; Release
• ISSN: 0170-0839; 1436-2449
• DOI: 10.1007/s00289-011-0549-1

Hydrogels of semi-interpenetrating networks composed of poly(acrylamide) (PAAm) and poly(γ-glutamic acid) (γ-PGA) with different proportions were studied as potential amoxicillin controlled-release devices. The effects of the hydrogels composition, pH, and temperature on the kinetics and final release of amoxicillin were determined in batch experiments. The release kinetic tests were conducted using a buffer solution as the release medium under pH conditions of 3 and 7.2, and temperature of 25, 37, and 45 °C. The final percentage of amoxicillin released from the hydrogels was found to increase with temperature, pH, and the amount of γ-PGA in the hydrogels formulation. Overall, equilibrium conditions in the kinetics experiments were achieved within 240 min of hydrogel–solution contact. The overall rate of amoxicillin release was represented with a two-parameter empirical model as a function of time.