pH- and temperature-sensitive semi-interpenetrating network hydrogels composed of poly(acrylamide) and poly(γ-glutamic acid) as amoxicillin controlled-release system
Hydrogels of semi-interpenetrating networks composed of poly(acrylamide) (PAAm) and poly(γ-glutamic acid) (γ-PGA) with different proportions were studied as potential amoxicillin controlled-release devices. The effects of the hydrogels composition, pH, and temperature on the kinetics and final relea...
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Published in | Polymer bulletin (Berlin, Germany) Vol. 68; no. 1; pp. 197 - 207 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Berlin/Heidelberg
Springer-Verlag
2012
Springer Springer Nature B.V |
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Abstract | Hydrogels of semi-interpenetrating networks composed of poly(acrylamide) (PAAm) and poly(γ-glutamic acid) (γ-PGA) with different proportions were studied as potential amoxicillin controlled-release devices. The effects of the hydrogels composition, pH, and temperature on the kinetics and final release of amoxicillin were determined in batch experiments. The release kinetic tests were conducted using a buffer solution as the release medium under pH conditions of 3 and 7.2, and temperature of 25, 37, and 45 °C. The final percentage of amoxicillin released from the hydrogels was found to increase with temperature, pH, and the amount of γ-PGA in the hydrogels formulation. Overall, equilibrium conditions in the kinetics experiments were achieved within 240 min of hydrogel–solution contact. The overall rate of amoxicillin release was represented with a two-parameter empirical model as a function of time. |
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AbstractList | Hydrogels of semi-interpenetrating networks composed of poly(acrylamide) (PAAm) and poly(γ-glutamic acid) (γ-PGA) with different proportions were studied as potential amoxicillin controlled-release devices. The effects of the hydrogels composition, pH, and temperature on the kinetics and final release of amoxicillin were determined in batch experiments. The release kinetic tests were conducted using a buffer solution as the release medium under pH conditions of 3 and 7.2, and temperature of 25, 37, and 45 °C. The final percentage of amoxicillin released from the hydrogels was found to increase with temperature, pH, and the amount of γ-PGA in the hydrogels formulation. Overall, equilibrium conditions in the kinetics experiments were achieved within 240 min of hydrogel–solution contact. The overall rate of amoxicillin release was represented with a two-parameter empirical model as a function of time. Hydrogels of semi-interpenetrating networks composed of poly(acrylamide) (PAAm) and poly(γ-glutamic acid) (γ-PGA) with different proportions were studied as potential amoxicillin controlled-release devices. The effects of the hydrogels composition, pH, and temperature on the kinetics and final release of amoxicillin were determined in batch experiments. The release kinetic tests were conducted using a buffer solution as the release medium under pH conditions of 3 and 7.2, and temperature of 25, 37, and 45 °C. The final percentage of amoxicillin released from the hydrogels was found to increase with temperature, pH, and the amount of γ-PGA in the hydrogels formulation. Overall, equilibrium conditions in the kinetics experiments were achieved within 240 min of hydrogel–solution contact. The overall rate of amoxicillin release was represented with a two-parameter empirical model as a function of time. |
Author | Pérez-Martínez, C. J. Castillo-Ortega, M. M. Romero-García, J. Rodríguez-Félix, F. Rodríguez-Félix, D. E. Del Castillo-Castro, T. Ledezma-Pérez, A. S. Pérez-Tello, M. |
Author_xml | – sequence: 1 givenname: D. E. surname: Rodríguez-Félix fullname: Rodríguez-Félix, D. E. email: dora@polimeros.uson.mx organization: Departamento de Investigación en Polímeros y Materiales, Universidad de Sonora – sequence: 2 givenname: C. J. surname: Pérez-Martínez fullname: Pérez-Martínez, C. J. organization: Departamento de Investigación en Polímeros y Materiales, Universidad de Sonora – sequence: 3 givenname: M. M. surname: Castillo-Ortega fullname: Castillo-Ortega, M. M. organization: Departamento de Investigación en Polímeros y Materiales, Universidad de Sonora – sequence: 4 givenname: M. surname: Pérez-Tello fullname: Pérez-Tello, M. organization: Departamento de Ingeniería Química y Metalurgia, Universidad de Sonora – sequence: 5 givenname: J. surname: Romero-García fullname: Romero-García, J. organization: Centro de Investigación en Química Aplicada – sequence: 6 givenname: A. S. surname: Ledezma-Pérez fullname: Ledezma-Pérez, A. S. organization: Centro de Investigación en Química Aplicada – sequence: 7 givenname: T. surname: Del Castillo-Castro fullname: Del Castillo-Castro, T. organization: Departamento de Investigación en Polímeros y Materiales, Universidad de Sonora – sequence: 8 givenname: F. surname: Rodríguez-Félix fullname: Rodríguez-Félix, F. organization: Departamento de Investigación y Posgrado en Alimentos, Universidad de Sonora |
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Cites_doi | 10.1016/0168-3659(87)90034-4 10.1016/j.snb.2008.02.045 10.1016/S0169-409X(01)00112-0 10.1016/j.jconrel.2004.06.022 10.1016/S0168-3659(00)00208-X 10.1016/j.polymer.2006.08.056 10.1016/j.matlet.2005.11.033 10.1002/(SICI)1099-0518(19960730)34:10<2019::AID-POLA19>3.0.CO;2-K 10.1016/j.ijpharm.2005.04.006 10.1002/mame.200600063 10.1016/j.carbpol.2007.02.016 10.1016/0168-3659(87)90035-6 10.1002/app.33006 |
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Keywords | Semi-interpenetrating networks Amoxicillin controlled release Polymer gels Poly(acrylamide) Poly(γ-glutamic acid) Control release polymer Temperature effect Drug carrier pH effect Semiinterpenetrating polymer network Experimental study Empirical model Modeling Aminoacid polymer Antibiotic Amoxicillin Acrylamide polymer Glutamic acid polymer Kinetics Hydrogel Release |
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References | Huang, Yu, Xiao (CR5) 2007; 69 Ritger, Peppas (CR12) 1987; 5 Gonzales, Fan, Sevoian (CR9) 1996; 34 Risbud, Hardikar, Bhat, Bhonde (CR1) 2000; 68 Liu, Lin, Li, Liu (CR4) 2005; 298 Ritger, Peppas (CR11) 1987; 5 Santos, Bergamini, Zanoni (CR3) 2008; 133 Rodríguez, Romero-García, Ramirez-Vargas, Ledezma-Pérez, Arias-Marín (CR8) 2006; 60 Rodríguez–Félix, Castillo-Ortega, Real-Félix, Romero-García, Ledezma-Pérez, Rodríguez-Félix (CR10) 2011; 119 Zhao, Kang, Tan (CR6) 2006; 47 Caykara, Sengül, Birlik (CR7) 2006; 291 Siepmann, Peppas (CR13) 2001; 48 Liu, Lu, Qian, Zhang, Zeng, Pan (CR2) 2005; 102 DE Rodríguez (549_CR8) 2006; 60 Y Zhao (549_CR6) 2006; 47 PL Ritger (549_CR12) 1987; 5 J Siepmann (549_CR13) 2001; 48 Z Liu (549_CR2) 2005; 102 549_CR10 PL Ritger (549_CR11) 1987; 5 DP Santos (549_CR3) 2008; 133 D Gonzales (549_CR9) 1996; 34 MV Risbud (549_CR1) 2000; 68 Y Huang (549_CR5) 2007; 69 T Caykara (549_CR7) 2006; 291 J Liu (549_CR4) 2005; 298 |
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and poly(acrylic acid) publication-title: Polymer doi: 10.1016/j.polymer.2006.08.056 contributor: fullname: Tan – volume: 60 start-page: 1390 year: 2006 end-page: 1393 ident: CR8 article-title: Synthesis and swelling characteristics of semi-interpenetrating polymer network hydrogels composed of poly(acrylamide) and poly(γ-glutamic acid) publication-title: Mater Lett doi: 10.1016/j.matlet.2005.11.033 contributor: fullname: Arias-Marín – volume: 34 start-page: 2019 year: 1996 end-page: 2027 ident: CR9 article-title: Synthesis and swelling characterizations of a poly(gamma-glutamic acid) hydrogel publication-title: J Polym Sci A Polym Chem doi: 10.1002/(SICI)1099-0518(19960730)34:10<2019::AID-POLA19>3.0.CO;2-K contributor: fullname: Sevoian – volume: 298 start-page: 117 year: 2005 end-page: 125 ident: CR4 article-title: Release of theophylline from polymer blend hydrogels publication-title: Int J Pharm doi: 10.1016/j.ijpharm.2005.04.006 contributor: fullname: Liu – volume: 291 start-page: 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Y Zhao – volume: 34 start-page: 2019 year: 1996 ident: 549_CR9 publication-title: J Polym Sci A Polym Chem doi: 10.1002/(SICI)1099-0518(19960730)34:10<2019::AID-POLA19>3.0.CO;2-K contributor: fullname: D Gonzales – volume: 133 start-page: 398 year: 2008 ident: 549_CR3 publication-title: Sens Actuators B Chem doi: 10.1016/j.snb.2008.02.045 contributor: fullname: DP Santos – volume: 68 start-page: 23 year: 2000 ident: 549_CR1 publication-title: J Control Release doi: 10.1016/S0168-3659(00)00208-X contributor: fullname: MV Risbud – volume: 5 start-page: 23 year: 1987 ident: 549_CR11 publication-title: J Control Release doi: 10.1016/0168-3659(87)90034-4 contributor: fullname: PL Ritger – ident: 549_CR10 doi: 10.1002/app.33006 – volume: 102 start-page: 135 year: 2005 ident: 549_CR2 publication-title: J Control Release doi: 10.1016/j.jconrel.2004.06.022 contributor: fullname: Z Liu |
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SubjectTerms | Acids Acrylamide Aminoacid polymers Amoxicillin Antibiotics Applied sciences Aqueous solutions Biological and medical sciences Buffer solutions Calibration Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Complex Fluids and Microfluidics Equilibrium Equilibrium conditions Exact sciences and technology Experiments General pharmacology Glutamic acid Hydrogels Interpenetrating networks Kinetics Mechanical properties Medical sciences Organic Chemistry Original Paper Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Physical Chemistry Physicochemistry of polymers Polymer Sciences Polymers Soft and Granular Matter Synthetic biopolymers |
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Title | pH- and temperature-sensitive semi-interpenetrating network hydrogels composed of poly(acrylamide) and poly(γ-glutamic acid) as amoxicillin controlled-release system |
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