The hybridization between peptide nucleic acid containing azobenzene and DNA labeled nanoparticle on chip surfaces studied by atomic force microscopy

• Published in: Chinese science bulletin Vol. 53; no. 19; pp. 3077 - 3080
• Main Authors: Li, JinDu, Chen, Miao, Zhang, HaoBo, Liu, Sheng, Liu, JianXi
• Format: Journal Article
• Language: English
• Published: Heidelberg SP Science in China Press 01.10.2008
• Subjects: Chemistry/Food Science; Earth Sciences; Engineering; Humanities and Social Sciences; Life Sciences; multidisciplinary; Physics; Science; Science (multidisciplinary); 偶氮苯; 异构化作用; 显微镜; 缩氨酸; azobenzene; atomic force microscopy; isomerization; peptide nucleic acid
• ISSN: 1001-6538; 2095-9273; 1861-9541; 2095-9281
• DOI: 10.1007/s11434-008-0432-0

Peptide nucleic acid containing azobenzene （N-PNA） was covalently bound on chip surfaces. Complementary DNA probes labeled by gold nanoparticles hybridizated with PNA on chip surfaces, The hybridization was successfully detected with AFM by the microscopy mothed. The influences of the position and t...