The hybridization between peptide nucleic acid containing azobenzene and DNA labeled nanoparticle on chip surfaces studied by atomic force microscopy

Peptide nucleic acid containing azobenzene （N-PNA） was covalently bound on chip surfaces. Complementary DNA probes labeled by gold nanoparticles hybridizated with PNA on chip surfaces, The hybridization was successfully detected with AFM by the microscopy mothed. The influences of the position and t...

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Bibliographic Details
Published inChinese science bulletin Vol. 53; no. 19; pp. 3077 - 3080
Main Authors Li, JinDu, Chen, Miao, Zhang, HaoBo, Liu, Sheng, Liu, JianXi
Format Journal Article
LanguageEnglish
Published Heidelberg SP Science in China Press 01.10.2008
Subjects
Chemistry/Food Science
Earth Sciences
Engineering
Humanities and Social Sciences
Life Sciences
multidisciplinary
Physics
Science
Science (multidisciplinary)
偶氮苯
异构化作用
显微镜
缩氨酸
azobenzene
atomic force microscopy
isomerization
peptide nucleic acid
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Summary:Peptide nucleic acid containing azobenzene （N-PNA） was covalently bound on chip surfaces. Complementary DNA probes labeled by gold nanoparticles hybridizated with PNA on chip surfaces, The hybridization was successfully detected with AFM by the microscopy mothed. The influences of the position and the cis-trans isomerization of azobenzene unit on hybridization were investigated with AFM.
Bibliography:peptide nucleic acid, azobenzene, isomerization, atomic force microscopy
11-1785/N
O62
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1001-6538
2095-9273
1861-9541
2095-9281
DOI:10.1007/s11434-008-0432-0