Biological Evaluation of a Series of Amine-Containing Mixed-Ligand Copper(II) Coordination Compounds with 2-(2-hydroxybenzylidene)-N-(prop-2-en-1-yl)hydrazinecarbothioamide

• Published in: Microscopy and microanalysis Vol. 28; no. 5; pp. 1696 - 1702
• Main Authors: Gulea, Aurelian, Toderas, Ion, Garbuz, Olga, Ulchina, Ianina, Graur, Vasilii, Railean, Nadejda
• Format: Journal Article
• Language: English
• Published: New York, USA Cambridge University Press 01.10.2022; Oxford University Press
• Subjects: Anticancer properties; Antitumor activity; Bioassays; Biological Applications; Cancer therapies; Cations; Cell growth; Chemotherapy; Coordination compounds; Cytotoxicity; Doxorubicin; Drug dosages; Ligands; Nitrates; Physiology; Selectivity; Spectrum analysis; Toxicity; Tumor cell lines; toxicity; anticancer compound; selective activity; antioxidant activity; antiproliferative activity
• ISSN: 1431-9276; 1435-8115
• DOI: 10.1017/S1431927622000733

Five compounds 2-(2-hydroxybenzylidene)-N-(prop-2-en-1-yl)hydrazinecarbothioamide (H2L), bis[μ2-2-({2-[(prop-2-en-1-yl)carbamothioyl]hydrazinylidene}methyl)phenolato-S,N,O:O]diaquadicopper(II) nitrate (1), bis[μ2-2-({2-[(prop-2-en-1-yl)carbamothioyl]hydrazinylidene}methyl)phenolato-S,N,O:O]diimidazoldicopper(II) nitrate (2), bis[μ2-2-({2-[(prop-2-en-1-yl)carbamothioyl]-hydrazinylidene}methyl)phenolato-S,N,O:O]bis-(3,5-dibromopyridine)dicopper(II) nitrate (3), bis[μ2-2-({2-[(prop-2-en-1-yl)carbamothioyl]-hydrazinylidene}methyl)phenolato-S,N,O:O]bis(4-methylpyridine)dicopper(II) nitrate hexahydrate (4) were synthesized. The antiproliferative properties of these compounds toward cancer cell lines RD, HeLa, and normal cell line MDCK have been investigated. The tested complexes surpass Doxorubicin (DOXO) in the efficiency of anticancer activity as their IC50 values toward cancer cells are lower than the corresponding values of DOXO and the selectivity indexes exceed the corresponding SI value of DOXO. The tested compounds demonstrated a high antioxidant effect against ABTS•+ radical cations as well as low toxicity on Daphnia magna.