Trifluoroacetic Acid as an Efficient Catalyst for One-Pot, Four-Component Synthesis of 1,2,4,5-Tetrasubstituted Imidazoles Under Microwave-Assisted, Solvent-Free Conditions

An efficient method for synthesis of various tetrasubstituted imidazoles, using trifluoroacetic acid (TFA) as a catalytic support, by four-component condensation of benzil, aldehydes, amines, and ammonium acetate under microwave-irradiated, solvent-free conditions is described.

Saved in:
Bibliographic Details
Published inSynthetic communications Vol. 39; no. 18; pp. 3232 - 3242
Main Authors Mohammadizadeh, Mohammad R., Hasaninejad, Alireza, Bahramzadeh, M.
Format Journal Article
LanguageEnglish
Published PHILADELPHIA Taylor & Francis Group 20.08.2009
Taylor & Francis
Subjects
Chemistry
Chemistry, Organic
Four-component
microwave
Physical Sciences
Science & Technology
solvent-free
tetrasubstituted imidazoles
trifluoroacetic acid
REAGENT
SYSTEM
Four-component
ONE-STEP SYNTHESIS
6-AMINOURACILS
tetrasubstituted imidazoles
solvent-free
TFA
MILD
trifluoroacetic acid
HIGHLY-EFFICIENT
DERIVATIVES
microwave
SUBSTITUTED IMIDAZOLES
Online AccessGet full text

Cover

More Information
Summary:An efficient method for synthesis of various tetrasubstituted imidazoles, using trifluoroacetic acid (TFA) as a catalytic support, by four-component condensation of benzil, aldehydes, amines, and ammonium acetate under microwave-irradiated, solvent-free conditions is described.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397910902737122