Neutrophil infiltration into human gliomas

• Published in: Acta neuropathologica Vol. 98; no. 4; pp. 349 - 354
• Main Authors: FOSSATI, G, RICEVUTI, G, EDWARDS, S. W, WALKER, C, DALTON, A, ROSSI, M. L
• Format: Journal Article
• Language: English
• Published: Berlin Springer 01.10.1999; Springer Nature B.V
• Subjects: Biological and medical sciences; Bone Marrow - pathology; Brain Neoplasms - blood supply; Brain Neoplasms - pathology; Cell Death - physiology; Glioblastoma; Glioblastoma - blood supply; Glioblastoma - pathology; Glioma; Glioma - blood supply; Glioma - pathology; Humans; Immunohistochemistry; Infiltration; Leukocyte Count; Leukocytes (neutrophilic); Medical sciences; Metastases; Necrosis; Neovascularization, Pathologic - pathology; Neurology; Neutrophil Infiltration - physiology; Neutrophils; Neutrophils - physiology; Peroxidase; Tumors; Tumors of the nervous system. Phacomatoses; Histological grading; Human; Immunohistochemistry; Pathology; Intracranial; Nervous system diseases; Glioma; Central nervous system disease; Histological type; Tumor; Exploration; Neutrophil
• ISSN: 0001-6322; 1432-0533
• DOI: 10.1007/s004010051093

Human gliomas were analysed for the infiltration of neutrophils using immunohistochemistry by staining sections for CD15-positive and myeloperoxidase-positive cells. Over 70% of all glioma samples analysed (n = 105) had significant neutrophil infiltration, but there was a marked and significant correlation between tumour grade and the extent of the neutrophil infiltration. In the low grade tumours only 40-50% had significant infiltration, while in glioblastoma multiforme over 85% of the samples analysed had significant infiltration. Numbers of neutrophils infiltrating glioblastoma multiforme tumours were also greater than in the other tumour groups. Circulating white blood cell counts were elevated above the normal range in all glioma patients, but this elevation was entirely due to increased numbers of circulating neutrophils. Again, the highest numbers of circulating neutrophils were seen in the glioblastoma multiforme patients. These experiments indicate that glioma-derived factors may directly or indirectly affect the number of circulating neutrophils and influence their infiltration into the tumours.