Design and Synthesis of Heterocyclic Conjugated Peptides as Novel Antimicrobial Agents
Antimicrobial peptides have been recognized as a novel class of antibiotics and several candidates are currently in clinical trials. In the present study, new antimicrobial compounds were synthesized by coupling quinazolinone moiety with the fragments of elastin sequences VP, GVP, VGVP and GVGVP. Th...
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| Published in | International journal of peptide research and therapeutics Vol. 15; no. 1; pp. 25 - 30 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Dordrecht
Springer Netherlands
01.03.2009
Springer Nature B.V |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Antimicrobial peptides have been recognized as a novel class of antibiotics and several candidates are currently in clinical trials. In the present study, new antimicrobial compounds were synthesized by coupling quinazolinone moiety with the fragments of elastin sequences VP, GVP, VGVP and GVGVP. They were evaluated for their antibacterial activity against both gram positive and gram negative bacterial strains. We are here reporting that heterocyclic conjugated tetra peptide and penta peptide showed enhanced antibacterial activity compare to the conventional antimicrobial drugs. |
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| AbstractList | Antimicrobial peptides have been recognized as a novel class of antibiotics and several candidates are currently in clinical trials. In the present study, new antimicrobial compounds were synthesized by coupling quinazolinone moiety with the fragments of elastin sequences VP, GVP, VGVP and GVGVP. They were evaluated for their antibacterial activity against both gram positive and gram negative bacterial strains. We are here reporting that heterocyclic conjugated tetra peptide and penta peptide showed enhanced antibacterial activity compare to the conventional antimicrobial drugs. Antimicrobial peptides have been recognized as a novel class of antibiotics and several candidates are currently in clinical trials. In the present study, new antimicrobial compounds were synthesized by coupling quinazolinone moiety with the fragments of elastin sequences VP, GVP, VGVP and GVGVP. They were evaluated for their antibacterial activity against both gram positive and gram negative bacterial strains. We are here reporting that heterocyclic conjugated tetra peptide and penta peptide showed enhanced antibacterial activity compare to the conventional antimicrobial drugs. [PUBLICATION ABSTRACT] |
| Author | Suresha, G. P. Kapfo, Wethroe Channe Gowda, D. Shiva Kumara, K. N. Prakasha, K. C. |
| Author_xml | – sequence: 1 givenname: G. P. surname: Suresha fullname: Suresha, G. P. organization: Department of Studies in Chemistry, University of Mysore – sequence: 2 givenname: K. C. surname: Prakasha fullname: Prakasha, K. C. organization: Department of Studies in Chemistry, University of Mysore – sequence: 3 givenname: K. N. surname: Shiva Kumara fullname: Shiva Kumara, K. N. organization: Department of Studies in Chemistry, University of Mysore – sequence: 4 givenname: Wethroe surname: Kapfo fullname: Kapfo, Wethroe organization: Department of Studies in Chemistry, University of Mysore – sequence: 5 givenname: D. surname: Channe Gowda fullname: Channe Gowda, D. email: dchannegowda@yahoo.co.in organization: Department of Studies in Chemistry, University of Mysore |
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| Cites_doi | 10.1021/ac00098a003 10.1056/NEJMp048093 10.1016/j.mib.2003.08.003 10.1055/s-1980-29275 10.1080/713608148 10.1016/S1473-3099(01)00092-5 10.1074/jbc.M002998200 10.1128/AAC.46.11.3585-3590.2002 10.1021/jm0340039 10.1097/00062752-199704010-00009 10.1016/S0005-2736(99)00205-9 10.1038/431899a 10.1016/0952-7915(92)90115-U 10.1016/S0005-2736(99)00200-X 10.1002/(SICI)1097-0282(1998)47:6<451::AID-BIP4>3.0.CO;2-F 10.1021/jo010727l 10.1016/S0031-9422(00)83845-5 10.1016/S0040-4020(00)00595-0 10.1016/S0040-4039(99)00349-4 10.1080/07352689709701952 10.1128/AAC.40.8.1801 |
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| DOI | 10.1007/s10989-008-9158-8 |
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| Keywords | Antimicrobial drugs Synthesis Heterocyclic conjugated peptides |
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| References | Ross Kelly, Stephan, Richard (CR15) 1999; 40 Strom, Haug, Skar, Stensen, Stilberg, Svendsen (CR18) 2003; 46 Margareta, Li-ping, Charles (CR10) 2002; 46 Oren, Shai (CR13) 1998; 47 Michael (CR11) 1992; 4 Ganz, Lehrer (CR4) 1997; 4 Anwer, Spatola (CR1) 1980; 11 Jain, Koul, Dhar, Atal (CR6) 1980; 19 Krause, Beyermann, Dathe, Rothemund, Bienert (CR7) 1995; 67 Lemriss, Marquet, Ginestet, Lefeuvre, Fassouane, Boiron (CR9) 2003; 13 Broekaert, Cammue, Bolle, Thevissen, Samblanx, Osborn (CR3) 1997; 16 Lamberty, Zachary, Lanot, Boraereau, Robert, Hoffmann, Bullet (CR8) 2001; 276 Shai (CR17) 1999; 1462 Wenzel (CR21) 2004; 351 Urry, Channe Gowda, Hoban, Mekee, Williams, Olsen, Cox, Charles Gebelein (CR19) 1993 Projan (CR14) 2003; 6 Bechinger (CR2) 1999; 1462 Hancock (CR5) 2001; 1 Nathan (CR12) 2004; 431 Witt, Bergman (CR22) 2000; 56 Santhosh, Narasimha (CR16) 2001; 66 Vaara, Porro (CR20) 1996; 40 Z Michael (9158_CR11) 1992; 4 B Bechinger (9158_CR2) 1999; 1462 MK Anwer (9158_CR1) 1980; 11 MP Jain (9158_CR6) 1980; 19 T Ross Kelly (9158_CR15) 1999; 40 Y Shai (9158_CR17) 1999; 1462 T Ganz (9158_CR4) 1997; 4 Z Oren (9158_CR13) 1998; 47 RP Wenzel (9158_CR21) 2004; 351 BM Santhosh (9158_CR16) 2001; 66 E Krause (9158_CR7) 1995; 67 MB Strom (9158_CR18) 2003; 46 SJ Projan (9158_CR14) 2003; 6 M Lamberty (9158_CR8) 2001; 276 DW Urry (9158_CR19) 1993 S Lemriss (9158_CR9) 2003; 13 S Margareta (9158_CR10) 2002; 46 A Witt (9158_CR22) 2000; 56 C Nathan (9158_CR12) 2004; 431 WF Broekaert (9158_CR3) 1997; 16 REW Hancock (9158_CR5) 2001; 1 M Vaara (9158_CR20) 1996; 40 |
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contributor: fullname: T Ross Kelly – volume: 11 start-page: 929 year: 1980 ident: 9158_CR1 publication-title: Synthesis doi: 10.1055/s-1980-29275 contributor: fullname: MK Anwer – volume: 19 start-page: 1880 year: 1980 ident: 9158_CR6 publication-title: Phytochemistry doi: 10.1016/S0031-9422(00)83845-5 contributor: fullname: MP Jain – volume: 351 start-page: 523 year: 2004 ident: 9158_CR21 publication-title: N Engl J Med doi: 10.1056/NEJMp048093 contributor: fullname: RP Wenzel – volume: 1 start-page: 156 year: 2001 ident: 9158_CR5 publication-title: The Lancet Infect Dis doi: 10.1016/S1473-3099(01)00092-5 contributor: fullname: REW Hancock – volume: 13 start-page: 189 year: 2003 ident: 9158_CR9 publication-title: J Mycol Med contributor: fullname: S Lemriss – volume: 46 start-page: 3585 year: 2002 ident: 9158_CR10 publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.46.11.3585-3590.2002 contributor: fullname: S Margareta – volume: 56 start-page: 7245 year: 2000 ident: 9158_CR22 publication-title: Tetrahedron doi: 10.1016/S0040-4020(00)00595-0 contributor: fullname: A Witt |
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| SubjectTerms | Animal Anatomy Antibiotics Bacteria Biochemistry Biomedical and Life Sciences Biosynthesis Histology Life Sciences Molecular Medicine Morphology Peptides Pharmaceutical Sciences/Technology Pharmacology Pharmacology/Toxicology Polymer Sciences |
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| Title | Design and Synthesis of Heterocyclic Conjugated Peptides as Novel Antimicrobial Agents |
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