Design and Synthesis of Heterocyclic Conjugated Peptides as Novel Antimicrobial Agents

Antimicrobial peptides have been recognized as a novel class of antibiotics and several candidates are currently in clinical trials. In the present study, new antimicrobial compounds were synthesized by coupling quinazolinone moiety with the fragments of elastin sequences VP, GVP, VGVP and GVGVP. Th...

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Bibliographic Details
Published inInternational journal of peptide research and therapeutics Vol. 15; no. 1; pp. 25 - 30
Main Authors Suresha, G. P., Prakasha, K. C., Shiva Kumara, K. N., Kapfo, Wethroe, Channe Gowda, D.
Format Journal Article
LanguageEnglish
Published Dordrecht Springer Netherlands 01.03.2009
Springer Nature B.V
Subjects
Animal Anatomy
Antibiotics
Bacteria
Biochemistry
Biomedical and Life Sciences
Biosynthesis
Histology
Life Sciences
Molecular Medicine
Morphology
Peptides
Pharmaceutical Sciences/Technology
Pharmacology
Pharmacology/Toxicology
Polymer Sciences
Antimicrobial drugs
Synthesis
Heterocyclic conjugated peptides
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Summary:Antimicrobial peptides have been recognized as a novel class of antibiotics and several candidates are currently in clinical trials. In the present study, new antimicrobial compounds were synthesized by coupling quinazolinone moiety with the fragments of elastin sequences VP, GVP, VGVP and GVGVP. They were evaluated for their antibacterial activity against both gram positive and gram negative bacterial strains. We are here reporting that heterocyclic conjugated tetra peptide and penta peptide showed enhanced antibacterial activity compare to the conventional antimicrobial drugs.
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ISSN:1573-3149
1573-3904
DOI:10.1007/s10989-008-9158-8