Unraveling V(D)J Recombination: Insights into Gene Regulation

V(D)J recombination assembles antigen receptor genes from component gene segments. We review findings that have shaped our current understanding of this remarkable mechanism, with a focus on two major reports—the first detailed comparison of germline and rearranged antigen receptor loci and the disc...

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Bibliographic Details
Published inCell Vol. 116; no. 2; pp. 299 - 311
Main Authors Jung, David, Alt, Frederick W
Format Book Review Journal Article
LanguageEnglish
Published United States Elsevier Inc 23.01.2004
Subjects
Animals
antigen receptors
B-Lymphocytes - physiology
Cloning, Molecular
DNA Damage
Gene Expression Regulation
Genes, RAG-1 - genetics
Genes, RAG-1 - physiology
Humans
Models, Biological
Models, Genetic
Neoplasms - genetics
Receptors, Antigen
recombination activating gene-1
Recombination, Genetic
Structure-Activity Relationship
T-Lymphocytes - physiology
VDJ Recombinases - metabolism
VDJ Recombinases - physiology
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Summary:V(D)J recombination assembles antigen receptor genes from component gene segments. We review findings that have shaped our current understanding of this remarkable mechanism, with a focus on two major reports—the first detailed comparison of germline and rearranged antigen receptor loci and the discovery of the recombination activating gene-1.
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ISSN:0092-8674
1097-4172
DOI:10.1016/S0092-8674(04)00039-X