Fractional laser microablation of skin: increasing the efficiency of transcutaneous delivery of particles

• Published in: Quantum electronics (Woodbury, N.Y.) Vol. 46; no. 6; pp. 502 - 509
• Main Authors: Genina, E.A., Dolotov, L.E., Bashkatov, A.N., Tuchin, V.V.
• Format: Journal Article
• Language: English
• Published: United States Turpion Ltd and the Russian Academy of Sciences 01.01.2016
• Subjects: ABLATION; ALUMINIUM OXIDES; BEAMS; delivery of micro- and nanoparticles; fractional laser microablation; hydrodynamic shock wave; HYDRODYNAMICS; Lasers; MATERIALS SCIENCE; NANOPARTICLES; Nanostructure; NEODYMIUM LASERS; optical coherence tomography; Penetration; Position (location); PULSES; SHOCK WAVES; SKIN; Titanium dioxide; TITANIUM OXIDES; TOMOGRAPHY; Zirconium dioxide; ZIRCONIUM OXIDES
• ISSN: 1063-7818; 1468-4799
• DOI: 10.1070/QEL16109

We study several regimes of fractional laser microablation using a pulsed Er : YAG laser for producing microchannels of different depth and incisions that allow transcutaneous delivery of particles of different size, namely, (smaller than ) and (smaller than ). The shock wave regime was used both for enhancing the penetration of particles into the ablation zones and as an independent method of particle delivery into the skin. Based on optical coherence tomography we assessed the coherent depth of particle detection in the skin in , and after the administration. The maximal localisation depth (up to ) was obtained for nanoparticles in the regime of incisions with enhancement of particle penetration by pulses of a multiple-beam hydrodynamic shock wave. The results of the study can be useful for developing new methods of transcutaneous delivery of micro- and nanocarriers of medicinal preparations.