Relationships between cardiovascular signs and neurological signs in asphyxiated neonates in Ilorin, North Central Nigeria

• Published in: African health sciences Vol. 21; no. 2; pp. 743 - 752
• Main Authors: Issa, Amudalat, Abdulkadir, Mohammed Baba, Adesiyun, Omotayo Olukemi, Owolabi, Bilkis, Suberu, Habibat, Alabi, Kayode Olusegun, Bakare, Ruqayat Ronke
• Format: Journal Article
• Language: English
• Published: Uganda Makerere Medical School 01.06.2021
• Subjects: Asphyxia - complications; Asphyxia - mortality; Cardiovascular Diseases - physiopathology; Cross-Sectional Studies; Humans; Infant, Newborn; Nervous System Diseases - etiology; Nervous System Diseases - physiopathology; Nigeria; Severity of Illness Index; Nigeria; Perinatal asphyxia; Neurological outcomes; Cardiovascular signs; Mortality
• ISSN: 1680-6905; 1729-0503; 1680-6905
• DOI: 10.4314/ahs.v21i2.33

Perinatal asphyxia is a condition associated with multiple organ dysfunctions inclusive of cardiovascular dysfunction. Neurologic predictors of survival have been studied, but little has been reported regarding cardiovascular signs and their role in determining outcome in asphyxia. The study aimed to determine the relationship between cardiovascular signs and outcomes in asphyxiated newborns with hypoxic ischaemic encephalopathy. This was a cross sectional study involving asphyxiated new-born babies recruited within the first 24 hours of life. Hypoxic ischaemic encephalopathy staging was done using Sarnat and Sarnat staging. All patients had a detailed cardiovascular examination on admission, after initial resuscitation (30 - 60 minutes) into admission, and were followed till final outcome: discharge or death. Eighty-five asphyxiated new-borns with HIE were studied over seven months. Abnormal cardiovascular-related signs identified in the patients included respiratory distress (64.7%), small volume pulse (57.6%), hypotension (52.9%), hypoxemia (48.2%) and shock (32.9%). Five babies died. None of the clinical signs had a significant relationship with mortality. Abnormal cardiovascular signs increased with the progression of HIE staging but had no relationship with mortality.