Catalyst-Free Synthesis of α,α-bis(4-Hydroxycoumarin-3-yl)toluene in Aqueous Media Under Microwave Irradiation

An efficient catalyst-free synthesis of α,α -bis(4-hydroxycoumarin-3-yl)toluene was performed by the reaction of 4-hydroxycoumarin with aromatic aldehydes in aqueous media under microwave irradiation. The reaction was completed in short reaction time of 8-10 min with high yields of 76-94, was enviro...

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Bibliographic Details
Published inSynthetic communications Vol. 39; no. 3; pp. 497 - 505
Main Authors Gong, Gui-Xia, Zhou, Jian-Feng, An, Li-Tao, Duan, Xiu-Li, Ji, Shun-Jun
Format Journal Article
LanguageEnglish
Published PHILADELPHIA Taylor & Francis Group 13.01.2009
Taylor & Francis
Subjects
4-hydroxycoumarin
Aqueous media
aromatic aldehyde
bis(4-hydroxycoumarin-3-yl)toluene
Chemistry
Chemistry, Organic
microwave irradiation
Physical Sciences
Science & Technology
α,α
aromatic aldehyde
4-hydroxycoumarin
microwave irradiation
CONDENSATION
Aqueous media
INHIBITORS
alpha,alpha-bis(4-hydroxycoumarin-3-yl)toluene
CLAISEN REARRANGEMENT
DERIVATIVES
SOLVENT
WATER
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Summary:An efficient catalyst-free synthesis of α,α -bis(4-hydroxycoumarin-3-yl)toluene was performed by the reaction of 4-hydroxycoumarin with aromatic aldehydes in aqueous media under microwave irradiation. The reaction was completed in short reaction time of 8-10 min with high yields of 76-94, was environmental benign, and had easy workup. Their structures were confirmed by IR spectra, 1 H NMR, 13 C NMR, and elemental analysis.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397910802398272