Microwave assisted synthesis of N-(ethoxycarbonylmethyl)-nucleobases: building blocks for PNAs

The synthesis of N1/N9- (Ethoxycarbonylmethyl)pyrimidine/purine using as synthons for peptide nucleic acids has been described. Microwave irradiation provided the desired products by alkylation of the appropriately protected natural and substituted nucleobases with ethyl bromoacetate within 4-7 min...

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Bibliographic Details
Published inJournal of chemical research Vol. 2005; no. 3; pp. 167 - 168
Main Authors Qu, GR, Li, Y, Han, SH
Format Journal Article
LanguageEnglish
Published RUSHDEN Science Reviews 2000 Ltd 01.03.2005
Sage Publications Ltd
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
PEPTIDE NUCLEIC-ACID
alkylation
POLYAMIDE
THYMINE
PNAs
N-(ethoxycarbonylmethyl)-nucleobases
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Summary:The synthesis of N1/N9- (Ethoxycarbonylmethyl)pyrimidine/purine using as synthons for peptide nucleic acids has been described. Microwave irradiation provided the desired products by alkylation of the appropriately protected natural and substituted nucleobases with ethyl bromoacetate within 4-7 min in 48-85% yields.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:1747-5198
2047-6507
DOI:10.3184/0308234054213627