Serum IL-1β, IL-6, IL-8, and TNF-α Levels in Early Diagnosis and Management of Neonatal Sepsis

• Published in: Mediators of inflammation Vol. 2007; pp. 1 - 5
• Main Authors: Kurt, A. Nese Citak, Aygun, A. Denizmen, Godekmerdan, Ahmet, Kurt, Abdullah, Dogan, Yasar, Yilmaz, Erdal
• Format: Journal Article
• Language: English
• Published: Hindawi Limited 2007; Hindawi Publishing Corporation; Wiley
• Subjects: Bacterial infections; Complications and side effects; Development and progression; Diagnosis; Diseases; Evaluation; Health aspects; Immune response; Infants (Newborn); Inflammation; Interleukin-1; Interleukin-6; Interleukin-8; Physiological aspects; Risk factors; Sepsis; Tumor necrosis factor; Turkey
• ISSN: 0962-9351; 1466-1861
• DOI: 10.1155/2007/31397

Aim . To determine serum IL-1 β , IL-6, IL-8, and TNF- α levels in neonatal sepsis at the time of diagnosis and after therapy, and to show the meaningful on the follow up. Methods . This prospective study was performed on newborns who were hospitalized for neonatal sepsis and who were classified as culture-proven sepsis ( n = 12 ), as culture-negative sepsis ( n = 21 ), and as healthy newborns ( n = 17 ). Results . At the time of diagnosis, serum IL-1 β , IL-6, IL-8, and TNF- α levels of culture-proven sepsis were significantly higher than those of the control groups ( P < .05 ). At the time of diagnosis, IL-1 β , IL-6, IL-8, and TNF- α levels of culture-proven sepsis and culture-negative sepsis were significantly higher than levels at the seventh day after antibiotic treatment. Conclusion . Serum IL-1 β , IL-6, IL-8, and TNF- α are mediators of inflammation and can be used at the diagnosis and at the evaluation of the therapeutic efficiency in neonatal sepsis.