Effects of acetylsalicylic acid on serum paraoxonase activity, Ox-LDL, coenzyme Q10 and other oxidative stress markers in healthy volunteers

• Published in: Clinical biochemistry Vol. 43; no. 3; pp. 287 - 290
• Main Authors: Kurban, Sevil, Mehmetoglu, Idris
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier 01.02.2010
• Subjects: Adult; Antioxidants - metabolism; Aryldialkylphosphatase - metabolism; Aspirin - administration & dosage; Aspirin - metabolism; Biological and medical sciences; Biomarkers - blood; Carboxylic Ester Hydrolases - metabolism; Cardiovascular system; Fibrinolytic Agents - administration & dosage; Fibrinolytic Agents - metabolism; Humans; Lipoproteins, LDL - blood; Medical sciences; Middle Aged; Oxidative Stress; Pharmacology. Drug treatments; Ubiquinone - analogs & derivatives; Ubiquinone - blood; Vascular wall; Prostaglandin-endoperoxide synthase; Oxidative stress; Arylesterase; Volunteer; Biological marker; Cardiovascular disease; Coenzyme Q; Esterases; Acetylsalicylic acid; Dose activity relation; Vascular disease; Phosphoric triester hydrolases; Ubiquinone; Atherosclerosis; Serum; Salicylates; Aryldialkylphosphatase; Mechanism of action; Human; Healthy subject; Enzyme; Enzyme inhibitor; Paraoxonase; Antiplatelet agent; Carboxylic ester hydrolases; Non steroidal antiinflammatory agent; Analgesic; Oxidized LDL; Antipyretic; Hydrolases; Oxidoreductases
• ISSN: 0009-9120; 1873-2933; 1873-2933
• DOI: 10.1016/j.clinbiochem.2009.10.054

The aim of the study was to examine the effects of acetylsalicylic acid (ASA) on oxidative stress in healthy volunteers. 30 volunteers of which 17 received ASA as 100 mg/day (Group I) and 13 received ASA as 150 mg/day (Group II) for 2 months. Serum paraoxonase 1 (PON1), arylesterase, total antioxidant status (TAS), total oxidant status (TOS), oxidized LDL (Ox-LDL) and coenzyme Q(10) (CoQ(10)) levels were measured before and 1 and 2 months after treatment. There was no significant differences between the measured parameters of the groups. However, TOS and Ox-LDL levels of group II were significantly reduced after 2 months of treatment (p<0.05). Significantly inhibition of LDL oxidation and significantly reduction in TOS levels of group II after 2 months of ASA treatment shows that ASA treatment may contribute to the prevention of atherosclerosis, a beneficial effect which is dose and time dependent.